Am.  Jour.  Pharm.  \ 
December,  1900.  J 
Warburg  s  Tincture. 
575 
bisulfate,  which  is  equivalent  to  0-648  gramme  (10  grains)  of  quinine 
sulfate. 
A  sample  prepared  about  one  year  ago  was  recently  examined. 
It  was  perfectly  clear  but  for  a  slight  amount  of  sediment.  The 
specific  gravity  was  0-943  at  :5°  C.,  at  which  temperature  it  re- 
mained clear.  Ten  cubic  centimetres  on  evaporation  and  drying 
left  0-49  gramme  of  a  brittle  extract. 
A  commercial  sample  examined  some  time  ago  was  a  perfectly 
clear  reddish-brown  preparation  with  but  little  sediment.  It  con- 
tained 56  per  cent,  by  volume  or  48^  per  cent,  by  weight  of  abso- 
lute alcohol.  Ten  cubic  centimetres  yielded  0-4205  gramme  of  dry 
extract.    It  was  not  further  examined. 
Warburg's  Tincture  without  Aloes. — A  satisfactory  preparation  will 
result  by  following  the  above  formula  with  the  omission  of  the 
aloes.  Or,  if  it  is  desired  to  prepare  the  regular  tincture  from  this 
preparation  as  the  N.F.  directs,  Socotrine  aloes  should  be  employed 
in  preference  to  the  powdered  extract  of  aloes. 
Warburg's  Tincture  Modified. — This  preparation  is  also  known  as 
"  special  "  or  "altered  "  Warburg's  Tincture.  There  continues  to  be 
some  demand  for  this  preparation. 
It  can  be  prepared  by  following  the  above  formula  for  the  regular 
tincture,  but  substituting  for  the  quinine  sulfate  and  sulfuric  acid, 
66-66  grammes  of  each,  cinchonine  sulfate,  cinchonidine  sulfate  and 
chinoidine,  pure.    The  sulfuric  acid  is  not  necessary. 
This  tincture  is  somewhat  darker  in  color  than  the  regular  tinc- 
ture, and  possesses  a  feeble  alkaline  reaction,  which  is  due  to  the 
chinoidine  that  it  contains. 
There  is  also  some  demand  for  the  modified  tincture  without 
aloes. 
According  to  the  statement  of  one  manufacturing  firm,  their 
modified  Warburg's  Tincture  differs  from  the  original  in  that  many 
of  the  supposed  useless  ingredients  have  been  eliminated.  This 
tincture  contains  quinine  and  not  the  cheaper  alkaloids. 
In  conclusion,  the  writer  wishes  to  state  that  this  paper  is  not  in- 
tended to  present  an  argument  in  favor  of  preparing  all  tinctures  by 
maceration,  but,  in  his  experience,  a  few  other  tinctures  can  be  pre- 
pared of  proper  strength  and  of  more  satisfactory  appearance  by 
maceration  than  by  percolation. 
Laboratory  of  Lehn  &  Fink,"  New  York. 
