1 6 
Preparation  of  Dichloramin  T. 
/Am.  Jour.  Pharm. 
<■     January,  19 18. 
THE  PREPARATION  OF  DICHLORAMIN  T.  AND 
CHLORINATED  EUCALYPTOL  I.2.1 
By  Robert  B.  Krauss. 
From  the  Henry  Phipps  Institute  of  the  University  of  Pennsylvania. 
Para  toluol  sulphondichloramide  was  first  prepared  by  Kastle, 
Keiser  and  Bradey2  in  1896,  who  also  prepared  a  number  of  related 
compounds.  Since  its  introduction  under  the  name  of  dichloramin 
T.  by  Dakin,  Lee,  Sweet,  Hendricks  and  LeConte,3  the  production 
of  this  substance  on  a  large  scale  in  pure  form,  as  well  as  that  of 
suitable  solvents  for  its  application,  have  become  problems  of  im- 
portance. 
As  originally  used  for  this  purpose  dichloramin  T.  was  dis- 
solved in  a  prepared  eucalyptol  (chlorinated)  and  used  in  this  condi- 
tion or  further  diluted  with  prepared  paraffin  oil  (chlorinated). 
It  was  early  recognized  by  the  author  that  the  products  obtained 
bv  chlorination  may  vary  considerably,  according  to  the  conditions 
of  chlorination.  By  continued  chlorination,  under  certain  condi- 
tions, a  chlorinated  eucalyptol,  specific  gravity  1.2,  is  obtained,  which 
has  been  extensively  studied  by  surgeons.  As  a  solvent  for  dichlo- 
ramin T.  it  seems  to  have  all  the  desirable  qualities  with  the  excep- 
tion of  the  solution  being  definitely  stable.  There  seems  to  be  some 
reason  to  believe  that  chlorinated  eucalyptol  1.2  itself  has  some 
therapeutic  value. 
This  evening  I  will  present  an  outline  of  the  methods  for  pre- 
paring para-toluol-sulphon-dichloramide,  and  chlorinated  eucalyptol 
1:2,  and  the  specifications  for  both  as  prepared  for  federal  medical 
authorities. 
1.  Preparation  of  the  Sulphonic  Acids. 
Beginning  with  toluol,  the  sulphonic  acids  are  formed  by  mixing 
equal  parts  of  concentrated  sulphuric  acid  and  toluol.  On  shaking 
or  even  on  standing  the  toluol  dissolves  in  the  acid.    When  the  top 
1  Journal  of  the  American  Pharmaceutical  Association,  January,  1918.  Read 
before  the  Philadelphia  Branch  of  the  American  Pharmaceutical  Association. 
2  American  Chemical  Journal,  18,  491,  1896. 
3  Journal  American  Medical  Association,  69,  27,  1917. 
