j 8  Preparation  of  Dichloramin  T.  {AljaISaJ"yPi9i8m' 
the  use  of  chloroform  as  a  solvent.  It  was  developed  in  order  to 
produce  a  dichloramin  T.  which  would  be  comparatively  stable. 
The  product  has  a  negligible  ash  and  a  good  chlorine  content,  but  no 
free  chlorine  on  standing. 
Calculated  0  =  21.54  per  cent.,  Found  0  =  2142  per  cent.;  21.37 
per  cent. 
The  very  considerable  work  done  in  the  chemical  laboratory  of 
the  Institute  on  the  preparation  and  distribution  of  dichloramin  T. 
for  surgical  purposes  has  suggested  the  following  specifications  as 
most  suitable  for  this  material  when  used  as  a  disinfectant. 
Physical  Properties. 
White  powder  or  crystals  with  slight  yellow  green  tinge.  Melt- 
ing Point  78-84°  C. 
Chemical  Properties. 
Soluble  in  cold  chloroform  with  slight  to  no  turbidity.  (Any 
turbidity  must  be  removable  by  shaking  with  anhydrous  calcium 
chloride.)  Soluble  in  prepared  eucalyptol  Dakin  and  chlorinated 
eucalyptol  1.2.  Ash:  not  over  .2  per  cent.;  chlorine  content,  29.0 
per  cent,  to  29.54  per  cent. ;  calculated  CI  29.54  per  cent. 
The  solubility  in  chloroform  or  similar  organic  solvent  is  im- 
portant in  that  it  shows  presence  of  inorganic  impurities,  calcium 
salts,  etc.  Material  should  not  have  strong  odor  of  chlorine,  show- 
ing instability.  The  melting  point  may  vary  within  the  limits  in- 
dicated owing  to  moisture.  Sharp  drying  will  decompose  the  sub- 
stance. 
Solvents. 
The  eucalyptol,  as  first  proposed4  by  Dakin  and  Dunham,  was 
chlorinated  with  potassium  chlorate  and  hydrochloric  acid  accord- 
ing to  the  following  method: 
Five  hundred  Cc.  eucalyptol  (U.  S.  P.)  are  treated  with  15  Gm. 
potassium  chlorate  and  50  Cc.  concentrated  hydrochloric  acid.  After 
twelve  hours  the  oil  is  well  washed  with  water  and  sodium  car- 
bonate solution.  Dry  sodium  carbonate  is  added  to  the  oil  and  the 
mixture  is  allowed  to  stand  twenty-four  hours.  It  is  then  filtered 
and  dried  with  a  little  calcium  chloride. 
4  Dakin  and  Dunham,  British  Medical  Journal,  June,  1917. 
