344 
Urinary  A  n  Use p sis. 
Am.  Tour.  Pharm. 
May,  igi8. 
Dunning,  and  by  Clark  and  Lubs,  of  the  Bureau  of  Animal  Indus- 
try, Washington.  Other  compounds,  made  and  donated  through 
the  courtesy  of  Dr.  J.  H.  Sachs,  of  the  graduate  department  of 
chemistry,  Johns  Hopkins  University,  and  still  others,  obtained  here 
and  there  from  various  sources,  supplied  sufficient  material  for  the 
first  few  months  of  investigation,  and  gave  very  interesting  results. 
During  the  past  year,  however,  the  work  has  been  carried  out,  and 
is  at  present  being  continued,  with  the  collaboration  of  Dr.  E.  C. 
White,  chemist  in  the  Brady  Urological  Institute.  A  more  detailed 
report,  including  tables  of  antiseptic  values  and  rates  of  excretion, 
and  with  discussion  of  the  chemical  phases,  will  shortly  be  pub- 
lished as  a  joint  article. 
Although  the  literature  contains  no  record  of  any  attempt  to 
synthesize  an  internal  urinary  antiseptic,  various  workers  (follow- 
ing the  pioneer  work  of  Ehrlich  in  chemotherapy)  during  recent 
years  have  attempted  to  correlate  chemical  structure  and  physio- 
logic action,  and  thus  produce  compounds  with  a  desired  specific 
therapeutic  action.  It  is  not  my  purpose  to  discuss  this  literature. 
For  an  excellent  summary  of  recent  work  done  along  the  lines  of 
chemotherapy,  the  reader  is  referred  to  publications  of  Lewis.5 
The  problem  which  Lewis  and  his  co-worker,  Krauss,6  are  investi- 
gating is  analogous  to  the  problem  on  urinary  antisepsis  outlined 
above,  in  that  they  started  with  a  dye  (trypan  red)  which  possesses 
the  peculiar  property  of  becoming  localized  in  the  caseous  centers 
of  tuberculous  masses,  and  experimented  with  numerous  modifica- 
tions of  this  compound,  with  the  hope  that  one  might  be  produced 
that  would  inhibit  the  development  of  the  tubercle  bacillus,  and  still 
retain  the  localizing  tendency  of  the  original  compound. 
Limited  space  does  not  permit  a  discussion  of  the  so-called  uri- 
nary antiseptics  in  present  use,  and  of  the  great  need  of  a  really 
efficient  drug  for  this  purpose,  which  may  be  given  either  intrave- 
nously or  by  mouth  and  which  will  cause  an  inhibition  of  bacterial 
development  in  the  urine,  regardless  of  the  reaction  of  the  latter. 
For  a  complete  summary  of  this  phase  of  the  subject,  and  a  discus- 
5  Lewis,  P.  A.,  "  Observations  Bearing  on  the  Possibility  of  Developing 
an  Experimental  Chemotherapy  of  Tuberculosis,"  Bull.  Johns  Hopkins  Hosp., 
1917,  28,  120;  "Chemotherapy  in  Tuberculosis,"  Am.  Jour.  Med.  Sc.,  1917, 
153,  625. 
6  Krauss,  R.  B.,  "  The  Preparation  of  Compounds  of  Trypan  Red  with 
Iodin  and  Other  Substances,"  Jour.  Am.  Chem.  Soc,  1914,  36,  961. 
