Am.  Tour.  Pharm.  \ 
May,  1 9 1 8.  / 
Urinary  Antisepsis. 
351 
eliminated,  while  others  appear  in  the  urine  only  in  traces  or  not  at 
all.  The  excretion  seems  to  be  governed  by  no  rule.  With  this 
class  of  compounds,  no  definite  relationship  between  chemical  struc- 
ture and  "  renal  affinity  "  could  be  established.  The  addition  of 
methyl  groups  to  the  phenol  nucleus  (cresolsulphonephthalein)  cer- 
The  Excretion  and  the  Antiseptic  Properties  of  the  Sulphonephthaleins. 
Name. 
Phenolsulphonephthalein  
Thymolsulphonephthalein  
Salicylsulphonephthalein  
Hydrochinonsulphonephthalein  
Cresolsulphonephthalein  
Tetra-aminophenolsulphonephthalein 
Alphanaphtholsulphonephthalein  . .  . 
Orcinsulphonephthalein  
Pyrocatechinsulphonephthalein  ..... 
Tetranitrophenolsulphonephthalein  . 
Guaiacolsulphonephthalein  . 
Resorcinsulphonephthalein.  . 
Pyrogallolsulphonephthalein 
Phenol  
Antiseptic  Strength. 
In  Water 
Kills 
in  One 
Hour. 
1 :  200 
1:  200 
1: 180 
Fails 
in  One 
Hour. 
200 
1,000 
200 
200 
200 
I„,000 
1,000 
200 
5,000 
200 
1: 1,000 
1 : 200 
1 : 200 
1 : 200 
In  Urine. 
Inhibits 
Develop- 
ment. 
i :  900 
Permits 
Growth. 
i : 
200 
70 
1 : 
200 
Trace 
1: 
200 
Trace 
1: 
200 
40 
1 : 
200 
70 
1 ; 
500 
0 
1 : 
200 
Unstable 
1: 
200 
70 
1 : 
2,000 
0 
1 : 
200 
Hemo- 
globi- 
nuria 
1: 
200 
Trace 
1: 
200 
75 
1 : 
200 
30 
i: 
1,000 
tainly  does  not  interfere  with  excretion,  while  excretion  is  prevented 
by  isopropyl,  amino  and  carboxyl  groups,  as  shown  by  thymolsul- 
phonephthalein, aminosulphonephthalein  and  salicylsulphonephthal- 
ein. 
The  most  interesting  and  disappointing  feature  shown  by  the 
sulphonephthaleins  is  the  effect  of  the  addition  of  OH  groups  to  the 
phenol  nucleus.  Pyrogallolsulphonephthalein,  hydrochinonsulphone- 
phthalein and  pyrocatechinsulphonephthalein  are  all  hydroxy  deriva- 
tives, differing  only  in  the  number  and  position  of  the  OH  groups, 
and,  of  these,  the  pyrogallol  and  hydrochinon  compounds  are  ex- 
creted, whereas  pyrocatechinsulphonephthalein,  the  only  sulphone- 
phthalein  shown  to  be  antiseptic  in  urine,  unfortunately,  is  also  the 
only  one  not  excreted. 
Conclusions. — I.  Several  other  sulphonephthaleins  are  excreted 
by  the  kidney  with  great  rapidity,  just  as  is  phenolsulphonephthalein. 
2.  None  of  the  sulphonephthaleins  investigated  would  be  of  value 
