Am  Tour,  pharm.  |       Determination  of  Morphine. 
Nov.,  19 18.       J  it 
793 
Titration  results  : 
Total  acid  used  ==  16.50  Cc. 
Acid  equivalent  to  the  alkali  ==  7.41  Cc. 
Acid  equivalent  to  the  morphine  =  9.09  Cc. 
Weight  of  morphine  calculated  from  titration  =  0.2727  Gm. 
Equivalent  to  0.0614  Gm.  of  morphine  in  the  6  Gm.  of  pill  taken 
or  9.99  per  cent.     [Amount  actually  present  10  per  cent.] 
Experiment  25. — Only  0.0600  Gm.  of  morphine  was  used  in  this 
experiment,  the  weight  being  made  up  to  6  Gm.  by  the  addition  of 
Chinese  pills. 
The  determination  was  conducted  exactly  in  the  same  way  as  in 
Experiments  23  and  24,  except  that  only  four  extractions  were  made 
with  the  chloroform-alcohol  mixture. 
Titration  results 
Total  acid  used  =  10.30  Cc. 
Acid  equivalent  to  the  alkali  =  9.37  Cc. 
Acid  equivalent  to  the  morphine  —  0.93  Cc. 
Weight  of  morphine  found  by  titration  =  0.2799  Gm. 
Equivalent  to  0.0614  Gm.  of  morphine  in  the  6  Gm.  of  pill  taken 
or  1.02  per  cent.     [Amount  actually  present  1  per  cent.] 
Determination  of  Morphine  when  Present  as  Tartrate  and  Mixed 
with  a  Chinese  Pill  Mass.  Experiment  26. — Crystallized  morphine 
(0.3000  Gm.)  was  dissolved  in  a  little  tartaric  acid  solution.  Chi- 
nese pill  mass  (5.7  Gm.)  was  mixed  with  this,  and  the  analysis  of 
this  mixture  was  carried  on  as  in  Experiment  25. 
Titration  results  : 
Total  acid  used  =  15.00  Cc. 
Acid  equivalent  to  the  alkali  =  10.55  Cc. 
Acid  equivalent  to  the  morphine  ==  4.45  Cc. 
Weight  of  morphine  found  by  titration  ='  0.1335  Gm. 
Equivalent  to  0.2937  Gm.  of  morphine  in  the  6  Gm.  of  pill  taken 
or  4.89  per  cent.     [Amount  actually  present  5  per  cent.] 
Demonstration  that  Percentages  Found  Above  are  not  Increased 
by  Inclusion  of  Other  Bases  with  Morphine.  Experiment  27. — 
This  was  a  "  blank  "  experiment,  in  which  no  pill  mass  was  mixed 
with  the  morphine.  Crystallized  morphine  (0.6000  Gm.)  was  dis- 
solved in  a  little  dilute  sulphuric  acid.  The  solution  was  treated  as 
were  the  pill-mixtures  in  Experiments  25  and  26. 
