894  Current  Literature.  { Am-Je°^\g^rm' 
mice  intraperitoneally  and  into  guinea-pigs  both  subcutaneously  and 
intraperitoneally.  The  only  antiseptic  of  which  the  smallest  fatal 
dose  was  smaller  than  the  largest  survival  dose  was  dichloramin-T. 
Since  two  mice  survived  4.7  Mg.  per  100  Gm.  of  body  weight,  it  is 
probable  that  15.5  Mg.  rather  than  1.6  Mg.  is  to  be  considered  the 
smallest  fatal  dose  for  this  series.  Of  all  the  substances  tested, 
eucalyptol  and  brilliant  green  were  the  most  toxic,  the  lethal  dose  of 
each  being  0.1  Mg.  per  100  Mg.  of  body  weight.  Mercurophen, 
mercuric  chlorid,  and  chloramin-T  constitute  the  group  with  the  next 
highest  toxicity,  the  lethal  dose  being  1  Mg.  per  100  Gm.  of  body 
weight.  Dichloramin-T,  proflavine  and  the  four  hypochlorite  solu- 
tions tested  follow  in  the  order  named  with  a  lethal  dose  of  about 
10  to  15  Mg.  per  100  Gm.  of  body  weight.  The  least  toxic  chem- 
icals are  iodine  and  phenol,  of  which  the  lethal  doses  are  about  5c 
Mg.  per  100  Gm.  of  body  weight.  The  lethal  dose  of  Dakin's  hypo- 
chlorite solution  injected  under  the  skin  of  the  adbomen  of  guinea- 
pigs  per  100  Gm.  of  body  weight  is  the  same  as  that  determined 
intraperitoneally  in  the  mouse.  Chloramin-T  and  dichloramin-T 
administered  in  this  manner  gave  rise  to  local  necrosis  with  extensive 
sloughing.  Therefore,  the  substances  injected  intraperitoneally  into 
mice  and  guinea-pigs  arranged  in  the  order  of  their  decreasing 
toxicity  are :  eucalyptol  and  brilliant  green ;  dichloramin-T  and  pro- 
flavine ;  hypochlorite,  Dakin's  hypochlorite,  Javelle  water,  and  mag- 
nesium hypochlorite,  iodine,  and  phenol.  Now  that  Dakin's  bland 
solvent,  chlorcosane,  is  available  as  a  vehicle  for  dichloramin-T,  the 
authors  advise  that  eucalyptol  should  be  discarded  for  this  purpose 
"because  of  its  much  greater  toxicity.  (From  the  Journal  of  Exper- 
imental Medicine,  through  the  Journal  of  the  American  Medical  As- 
sociation.) 
Report  on  Carrel-Dakin  Solution. — Contrary  to  many  ob- 
servers the  authors  believe  that  the  Carrel  technic  is  not  a  compli- 
cated one.  It  requires  no  more  time,  labor  or  material  than  the 
method  of  treating  purulent  collections  with  drainage  tubes  and  irri- 
gations of  saline,  mercuric  bichloride  or  phenol  solutions.  The 
deodorizing  effect  of  this  solution  is  very  important.  This  has  a 
psychologic  effect  in  aiding  the  patients'  convalescence.  The  irri- 
tating effect  of  the  solution  on  skin  surfaces  has  been  very  slight. 
The  authors  have  abandoned  the  use  of  gauze  strips  saturated  with 
