434  The  Ne<w  Remedies  of  19 17.  {Amjiner'igih8arm" 
holds  that  its  sale  should  be  restricted.  Its  use  might  be  permitted 
in  liqueurs,  syrups,  and  the  like,  on  condition  that  the  amount  does 
not  exceed  one  centigram  to  the  tablespoonful,  and  that  the  exact 
amount  is  definitely  stated  on  the  label.  It  should  not  be  used  in 
cakes,  and  especially  in  those  containing  eggs.  Saccharinated  cakes 
and  pastry  are  very  indigestible. 
With  regard  to  its  use  medicinally,  Molliere  says  that  he  has 
prescribed  saccharin  for  over  ten  years,  and  has  never  yet  found  it 
to  cause  digestive  trouble  or  toxic  effects.  He  has,  however,  never 
prescribed  more  than  0.25  Gm.  per  diem.  The  success  obtained  by 
its  use  in  the  gastro-enteritis  of  infants  has  encouraged  him  to  test 
its  value  in  various  forms  of  dyspepsia  and  of  enteritis.  He  con- 
cludes that  saccharin  is  a  most  useful  aid  in  the  treatment  of  gastro- 
intestinal infections.  He  does  not  believe  that  it  is  in  any  way  in- 
jurious to  the  kidneys.  Neither  in  dyspepsia  nor  in  diabetes  does 
it  appear  to  have  any  bad  effect,  but  Molliere  has  taken  the  precau- 
tion not  to  prescribe  it  in  cases  of  albuminuria. 
Disodo-Luargol. — The  new  arsenobenzol-silver-antimony  com- 
pound Liiargol,  which  has  given  good  results  as  a  substitute  for 
salvarsan  in  syphilis  and  in  malaria,  was  described  in  The  Chemist's 
Annual,  191 7,  p.  48.  The  drug  is  given  by  intravenous  injection, 
the  dose  being  dissolved  in  an  excess  of  caustic  soda.  A  new  sol- 
uble form  of  luargol  has  been  introduced  under  the  name  of  Disodo- 
Luargol;  this  is  a  definite  sodium  compound,  freely  soluble  in  water, 
giving  a  brown  solution.  The  contents  of  an  ampoule  may  be  dis- 
solved in  sterile  water  and  injected  immediately  without  the  neces- 
sity of  filtration.  Injection  is  made  in  the  same  way  as  in  the  case 
of  salvarsan.  The  dose  to  commence  is  0.05  Gm.,  this  being  gradu- 
ally increased  until,  at  the  sixth  injection,  0.3  Gm.  is  reached.  Two 
injections  per  week  are  well  tolerated. 
Thorium  Sodio- Citrate. — The  double  citrate  of  thorium  and 
sodium,  being  opaque  to  the  X-rays  while  soluble  in  water,  is  used 
in  solution  for  pyelography.  The  solution  is  prepared  as  follows : 
Thorium  nitrate,  10  Gm.,  is  dissolved  in  distilled  water  and  heated 
on  the  water-bath;  30  Cc.  of  sodium  citrate  solution  (1:2)  is  then 
added  slowly  with  constant  agitation.  The  precipitate  formed  at 
first  is  redissolved  in  the  excess  of  the  alkali  citrate  solution.  The 
liquid  is  then  exactly  neutralized  with  normal  NaOH  solution,  and 
the  volume  made  up  to  100  Cc.  with  water.    After  filtration  and 
