AmjJ?y,r"iJih8!rm')      American  Acctylsalicylic  Acid.  525 
Melting  Point  and  Salicylic  Acid  Determinations. 
Mehing  Point  Free  Salicylic  Acid 
Brand.  Corrected.  Colorimetrically. 
Acetylsalicylic  acid,  P.  W.  R.12    130.0-131.00  Colored,  but  showing  less 
than  0.1  per  cent. 
Acetylsalicylic  acid,  Millikin13    130.0-131.00  No  color. 
Acetylsalicylic  acid,  Millikin13 
5-grain  capsules   129.0-130.00  No  color. 
Acetylsalicylic  acid,  Millikin12 
5-grain  capsules14   128.0-129.00  (a)     Colored,  but  showing  less 
125.5-126.50 (b)         than  0.1  per  cent.  (a). 
Considerably  more  than  0.1 
per  cent.  (b). 
Acetylsalicylic  acid,  Squibb13..     131.0-132.00  No  color. 
Acetylsalicylic  acid  (Aspirin) , 12 
Monsanto    131.0-132.00  No  color. 
Acetylsalicylic  acid,  M.  C.W.12    130.5-131.5°  Colored,  but  showing  less 
than  0.1  per  cent. 
Acetylsalicylic  acid,  M.  C.W.12    131.5-132.50  Colored,  but  showing  less 
than  0.1  per  cent. 
Acetylsalicylic  acid,  M.  C.W.12    131.0-132.00  Colored,  but  showing  less 
than  0.1  per  cent. 
Aspirin,  Bayer12  (before  patent 
expired)    131.5-132.50         No  color. 
Aspirin,  Bayer12*15  (after  pat- 
ent expired)    128.5-129.50  Colored,  but  showing  less 
than  0.1  per  cent. 
Aspirin,  Bayer12*15  (after  pat- 
ent expired)  . .   129.5-130.50  Colored,  but  showing  less 
than  0.1  per  cent. 
Aspirin,  Lehn  and  Fink13   130.5-131.50  0.1  per  cent. 
Aspirin,  Lehn  and  Fink13   130.5-131.50  Colored,  but  showing  less 
than  0.1  per  cent. 
Aspirin,  Lehn  and  Fink12   131.0-132.00  Colored,  but  showing  less 
than  0.1  per  cent. 
titative  comparisons  might  be  possible.  In  one  experiment,  after  60 
days  the  hydrolysis  of  the  acetylsalicylic  acid  was  61  per  cent.,  which 
is  in  rough  agreement  with  the  work  of  Tsaklatos  and  Horsh.16 
12  Obtained  on  the  open  market. 
13  Obtained  from  manufacturer. 
14  One  third  of  the  capsules  (a)  contained  a  white  powder;  two  thirds 
of  the  capsules  (b)  contained  a  pink  powder  having  strong  odor  of  acetic 
acid  and  not  complying  with  the  tests. 
15  Not  described  in  "  New  Nonofficial  Remedies  "  ;  the  other  products  are. 
16Apoth.  Ztg.,  1915,  p  247;  Bull  soc.  chim.,  17  (1915),  401.    "Studies  of 
the  decomposition  of  aspirin  determined  by  titrametric  methods  and  by  con- 
ductivity measurements  indicate  that  the  reaction  is  exceedingly  complex," 
T.  and  H.,  Chem.  Abs.,  10,  591. 
