An\uiust'  fgiT"'  )      Relative  Activity  of  Digitalis.  581 
Table  I. 
Guinea-pig  Assay  of  Select  Cleaned  Digitalis — Five  Per  Cent.  Infusion. 
Date  of  Test. 
Num 
ber. 
Weight 
of  Pig. 
Dose  of 
Drug  in 
250  Gm. 
Wt.  of  Pig. 
Dose  of 
Drug  in 
Gm.'  Wt. 
of  Pig. 
Actual 
Dose 
Given  in 
Mis.  of  5% 
Infusion. 
Results. 
2- 
-4-18,  12:10  A.M. 
3 
405 
.0875 
.OOO35 
2.835 
Died  12:43  a.m.,  33 
min. 
2- 
-4-18,  12:15  A.M. 
4 
390 
.0875 
.OOO35 
2-73 
Died  12:53  a.m.,  38 
min. 
2- 
-3-18,  11  :i5  p.m. 
1 
535 
•075 
.0003 
3.21 
Died,  2-4-18,  12:52 
a.m.,  57  min. 
2- 
-4-18,  12:05  A.M. 
2 
500 
•075 
.0003 
3.00 
Died  12:05  a.m.,  1  hr. 
2- 
-4-18,  10:10  P.M. 
10 
400 
.0625 
.OOO25 
2.00 
Died  11 :30  p.m.,  i  hr. 
20  min. 
2- 
-4-l8,  10:05  P.M. 
9 
750 
.050 
.0002 
3.OO 
Died,  2-5-18,  12:20 
a.m.,  2  hrs.  15  min. 
2- 
-5-l8,  2:30  P.M.  . 
16 
640 
•04375 
.OOOI75* 
2.24 
Died  4:30  p.m.,  2  hrs. 
2- 
-5-18,  5:15  P.M.  . 
i8f 
495 
•04375 
.OOOI75* 
i-73 
Died  7  :20  p.m.,  2  hrs. 
5  min. 
2- 
-I5-I8,  5:40  P.M. 
35 
420 
•04375 
.000175* 
1.47 
Recovered 
2- 
-5-18,  2:20  P.M.  . 
15 
630 
•0375 
.00015 
1.89 
Died  4:30  p.m.,  2  hrs. 
10  min. 
2- 
-5-l8,  5:07  P.M.  . 
i7t 
390 
•0375 
.00015 
1. 17 
Survived  36  hrs. 
2- 
-I5-I8,  5:43  P.M. 
36 
405 
•0375 
.00015 
1. 215 
Recovered 
2- 
-5-l8,  6:00  P.M.  . 
19 
720 
•03125 
.000125 
1.80 
Recovered 
2- 
-5-18,  6:05  P.M.  . 
20 
575 
.025 
.00010 
i-i5 
Recovered 
A  ten  per  cent,  infusion  of  the  petioles  separated  from  the  select 
clean  digitalis  was  made  and  tested  by  the  guinea-pig  method,  with 
the  following  results : 
.  *  M.  L.  D.  is  .04375  Gm.  of  select  clean  digitalis  per  250  Gm.  wt.  of 
guinea-pig,  or  .000175  Gm.  per  Gm.  wt.  of  pig. 
t  Infusion  prepared  from  capsule-filling  drug,  petioles  partly  removed. 
Note:  The  word  "cleaned"  as  used  in  the  title  of  this  table  refers  to 
drug  prepared  by  the  special  cleaning  process,  outlined  by  the  authors  in  a 
previous  paper. 
