ON ATROPINE. 89 
ing the pupil, one or two drops are to be introduced into 
the eye. 
Bouchardat recommends the following method of prepar- 
ing atropine. The atropine is to be precipitated by a 
watery solution of iodine in iodide of potassium, and the 
ioduretted hydriodate of atropine decomposed by zinc and 
water. The metallic oxide is separated by means of car- 
bonate of potash, and the alkaloid dissolved in alcohol. 
Rabbits are scarcely affected by atropine. Do'gs are 
soon poisoned by it. On man the effect is much stronger. 
One centigramme is able to produce the following symp- 
toms : At first, acceleration of the pulse by eight to twenty 
strokes ; after thirty to fifty minutes, an affection of the 
brain is produced. The first and most constant symptom 
is dry throat, with difficulty of swallowing. The second 
is dilatation of pupils, with increased power of vision, also 
giddiness, noise in the ears, hallucination, delirium, strari- 
guary, with incapacity of emitting the urine ; a sensation of 
formication in the arms, rigidity of the thighs, depression of 
the pulse. The unfavorable symptoms disappear after 
twelve to twenty hours. The sanatory effect of the atro- 
pine has chiefly been substantiated in chorea and other 
chronic nervous diseases. — Pharmaceutical Journal for 
November. 
*8 
