360 DEPRIVING QUININE OF ITS BITTERNESS. 
through which the muscular coat appeared ; the adjoining 
muscular membrane was inflamed. This surrounding in- 
flammation extended for sorne distance around, and 
gradually passed into the natural color. The nature of 
this change the author could not determine. In the small 
intestines the epithelium was found removed, and they 
contained only mucus. Besides these, the blood was found 
dark and slightly coagulated. The kidneys in their corti- 
cal substance, and the liver, were congested. 5. The most 
frequent symptoms of poisoning were — increase of the 
heart's impulse, slightly accelerated breathing, restlessness, 
evacuation of the contents of the larger intestines, no in- 
crease of the urinary excretion, muscular debility with loss 
of sensibility, loss of the frequency and strength of the 
heart's action, slow and difficult breathing, coldness of the 
extremities, and death without convulsions. The phenomena 
during life [are clearly attributable to the absorption of the 
oil, as the appearances discovered after death are not suffi- 
cient to account for the fatal effects. In a few cases where 
the dose is not fatal, the same symptoms in a less degree 
were observed, and were followed by obstinate costiveness. 
— London Med. Gaz., Nov. 1849, from Preuissische Vere- 
inszeitimg, No. 26, and Hays' Journal. 
ART. LXXXI. — METHOD OF DEPRIVING QUININE OF ITS 
BITTERNESS. 
By Richard H. Thomas, M. D., of Baltimore. 
Baltimore, Id mo. 1 5 th, 1850. 
To Dr. Isaac Hays : 
Dear Doctor — Believing that 1 have discovered a 
method, by which quinine may be quite deprived of its 
great bitterness, without injuring its virtues in the least, I 
