AMF^bUi;m4RM'|     Additional  Notes  on  Pancreatin,  53 
on  cooling.  When  slightly  heated,  it  volatilizes  unchanged  ;  at  a 
higher  temperature  it  takes  fire,  burning  with  a  yellow,  very  smoky 
flame  and  evolving  irritating  and  very  bitter  fumes.  It  is  soluble  in 
cold  water,  forming  a  solution  of  brighter  color  than  the  crystals 
themselves  ;  much  more  soluble  in  hot  water,  from  which  it  crystallizes 
in  thin  long  needles  on  cooling  ;  soluble  in  oil  of  vitriol  particularly 
when  heated,  and  precipitated  from  the  solution  in  the  original  state 
upon  addition  of  water.  With  aqueous  solutions  of  the  alkalies  it 
gives  bitter  deep  red  solutions.  Its  aqueous  solution,  treated  with 
excess  of  ferrous  sulphate,  then  with  excess  of  caustic  alkali,  gives  a 
filtrate  of  a  deep  blood  red  color,  darker  than  the  preceding  with 
alkalies  alone.  When  sulphuretted  hydrogen  is  passed  to  saturation 
into  a  saturated  alcoholic  solution  previously  neutralized  by  ammonia, 
the  liquid  assumes  an  intense  blood  red  color.  These  reactions  and 
characteristics  all  correspond  with  those  for  picric  acid. 
ADDITIONAL  NOTES  ON  PANCREATIN. 
By  Richard  Y.  Mattison. 
Read  at  the  Pharmaceutical  Meeting,  January  20th. 
Numerous  inquiries  regarding  saccharated  pancreatin,  its  doses, 
uses,  &c,  having  been  instituted  since  the  publication  of  my  last 
paper*  upon  the  subject,  induces  me  to  present  a  few  further  remarks 
upon  this  valuable  and  highly  interesting  substance.  This  is  a  fine 
white  powder,  almost  tasteless,  or  with  the  slightly  sweet  taste  of  lac- 
tin.  When  mixed  with  water  it  is  perfectly  soluble,  dissolving  in  be- 
tween five  and  six  parts  of  that  liquid,  and  forming  a  perfect  emul- 
sion when  mixed  with  liquid  fats  and  a  small  quantity  of  water. 
I  would  respectfully  suggest  the  following  formula  for  the  proper 
exhibition  of  cod-liver  oil  in  combination  with  pancreatin : 
R.    Pancreatini  Sacchar.,    .  .  .  ^j, 
Aquae,        ....  f^iv, 
Sacchari  Albi,  ....  ^vij, 
Olei  Morrhuse,        .  .  .  Oiss, 
"    Gaultherise,  .  .  .  gtt.  xx, 
"    Amygd.  Amar.  .  .  gtt.  v. 
M. 
*See  American  Journal  of  Pharmacy,  1873,  Dec,  p.  531. 
