116 
Combination  of  Lime  and  Glycerin,  etc. 
(  Am.  Jour.  Pharm. 
\    Mar.  1, 1874. 
COMBINATION  OF  LIME  AND  GLYCERIN,  AND  ITS  PHARMA- 
CEUTICAL APPLICATIONS* 
By  P.  Carles. 
The  recent  publication  of  a  note  upon  this  subjectf  has  induced 
the  author  to  put  on  record  some  experiments,  the  results  of  which 
were  communicated  orally  to  the  Paris  Societe*  d'Emulation  pour  les 
Sciences  Pharmaceutiques  in  1871,  but  have  not  hitherto  been  pub- 
lished. 
When  distilled  water  is  shaken  with  lime  under  normal  circum- 
stances it  only  dissolves  1*251  grams  per  litre  ;  but  this  proportion 
is,  however,  singularly  increased  by  the  intervention  of  neutral 
bodies,  such  as  the  sugars.  That  glycerin  also  acts  in  the  same  man- 
ner was  noticed  by  the  author,  and  gave  rise  to  the  following  experi- 
ments : 
Into  a  series  of  flasks  of  similar  capacity  were  placed  constant 
quantities  of  100  grams  of  distilled  water  and  20  grams  of  pure  lime, 
together  with  varying  proportions  of  glycerin,  0,  50,  100,  200,  400> 
etc.  The  flasks  were  labelled,  1,  2,  3,  4,  5.  After  agitation  of  the 
mixture  for  some  time  at  a  temperature  of  18°  C.  the  quantity  of 
lime  passed  into  solution  was  estimated  alkalimetrically,  and  found  to 
be- 
No.  1,   1-251 
"2,  1-865 
"3,  .  2-583 
"  4,  .  .  .  .  4-040 
"5,  .....  6-569 
Now,  if  each  of  these  numbers  be  reduced  by  1-251,  the  co-efli- 
cient  of  the  solubility  of  lime  in  water,  it  will  be  found  that  an  addi- 
tion of  50  parts  of  glycerin  to  1000  of  water  augments  by  nearly 
one-half  the  solubility  of  the  lime,  and  that  this  solubility  is  doubled 
by  the  addition  of  100  parts  of  glycerin  per  litre.  If  the  proportion 
of  glycerin  be  raised  beyond  200  parts  the  quantity  of  lime  dissolved 
is  still  sensibly  increased,  but  starting  from  that  figure  it  is  in  pro- 
portion irregularly  inverse  to  the  quantity  of  glycerin  added.  It  is 
the  author's  opinion  that  the  combination  of  glycerin  with  lime,  which 
*  Bulletin  de  la  Societe  de  Pharmacie  de  Bordeaux,  vol.  xiii,  p.  294. 
t  Pharm.  Journ.  [3],  vol.  iv,  p.  321.    See,  also,  Amer.  Journ.  Pharmacy, 
1873,  p.  397  and  557. 
