354 
Preparations  of  Strop hant hits. 
Am.  Jour.  Pharm. 
July,  1896. 
minute,  pressure  rose  5  mm.  more,  when  10  c.c.  were  administered, 
followed  in  one  minute  by  a  rise  of  7  mm.,  making  17  in  all.  Nine 
minutes  later,  the  pressure  had  fallen  almost  to  the  normal,  when 
20  c.c.  were  given  in  the  course  of  one  minute,  and  the  pressure 
began  to  rise.  Three  minutes  later,  it  was  18  mm.  above  the 
normal. 
Experiment  2. — Dog;  weight,  14  kilos. 
Arterial  pressure,  146;  5  c.c.  given;  no  distinct  effect.  In  three 
minutes,  5  c.c.  more  given  with  no  distinct  effect ;  in  seven  minutes, 
8  c.c.  more  given,  making  18  c.c.  in  ten  minutes.  One  minute  later, 
rise  of  6  mm. ;  one  minute  later,  further  rise  of  14  mm.,  making  20 
mm.  above  the  normal.  Two  minutes  later,  pressure  22  mm.  above 
the  normal.  Seven  minutes  later,  10  c.c.  were  given,  when  the 
pressure  began  to  fall  rapidly,  and  two  minutes  later  was  74  mm. 
below  the  normal.  The  dog  died  thirty  seconds  after  this,  of 
cardiac  arrest. 
Experiment  j — Dog;  weight,  8-6  kilos. 
Arterial  pressure,  146 ;  3  c.c.  given.  Three  minutes  later,  pressure 
20  mm.  above  the  normal ;  five  minutes  after  first  injection,  5  c.c. 
given ;  three  minutes  later  j  the  pressure  was  32  mm.  above  the 
normal.  Five  minutes  after  this,  the  pressure  was  10  mm.  above 
the  normal.  Another  5  c.c.  given ;  pressure  rose  in  one  minute  to 
46  mm.  above  the  normal;  half  a  minute  later,  was  52  mm.  above 
the  normal ;  one  minute  later,  was  56  mm.  above  the  normal.  Dog 
lived  for  twenty-four  minutes  after  this. 
Experiment  4.. —  Dog;  weight,  5-3  kilos. 
Spinal  cord  cut  so  as  to  produce  vasomotor  paralysis. 
Arterial  pressure,  22  ;  3  c.c.  in  one  minute  put  up  the  pressure  10 
mm.;  a  subsequent  injection  of  3  c.c.  more  was  followed  by  no  rise 
of  pressure,  which  was  steady  8  to  10  mm.  above  the  normal  for 
seven  minutes.  Another  3  c.c.  was  given ;  this  produced  a  steady 
pressure  of  from  10  to  12  mm.  above  the  normal.  In  thirteen 
minutes,  another  5  c.c.  was  given,  followed  by  a  rise  in  half  a  minute 
of  the  pressure  to  22  mm.  above  the  normal.  This  rise  amounted 
to  50  per  cent,  of  the  whole  pressure,  which  had  been  22  mm. 
(after  section  of  the  cord).    Dog  died  shortly  afterwards. 
An  examination  of  these  experiments  will  show  that  the  extract 
