356  Preparations  of  Strophantus.  {Am™y*"Sarm' 
Experiment  2. — Dog;  weight,  15-5  kilos. 
1  c.c  elevated  the  pressure  14  mm.  in  one  minute,  when  a  second 
1  c.c.  was  given ;  the  result  being  that  in  seven  minutes  the  pressure 
was  increased  62  mm.  above  the  normal.  After  this,  1  c.c.  was  ad- 
ministered, followed  by  cardiac  arrest  in  nine  minutes  and  ten 
seconds. 
Experiments  3,  4,  5,  6,  7,  were  made  with  a  solution  of  01  gramme 
in  1,000  c.c.  of  water;  of  this  solution,  therefore,  10  c.c.  equalled  1 
milligramme. 
Experiment  j. — Dog ;  weight,  7  kilos. 
Injected  into  the  jugular  2  c.c.  Pressure  in  five  minutes  rose  to  18 
mm.;  eight  minutes  after  first  injection,  a  second  of  3  c.c;  two 
minutes  after,  a  third  of  4  c.c.  Two  minutes  later,  pressure  was  40  mm. 
above  the  normal ;  then  began  to  fall  and  continued  to  fall,  although 
an  injection  of  5  c.c.  was  given,  and  five  minutes  later  another  of  3 
c.c.    One  minute  after  the  last  injection  the  heart  stopped. 
Experiment  4. — Dog;  weight,  17  kilos. 
5  c.c.  given.  One  minute  later,  pressure  rose  28  above  the  normal ; 
slowly  fell,  however,  so  that  ten  minutes  after  the  injection  the 
pressure  was  at  the  normal.  Another  5  c.c.  given,  and  three  min- 
utes later  8  c.c.  Pressure  began  to  rise,  and  in  two  and  one-half 
minutes  after  the  last  injection  it  was  43  mm.  above  the  normal. 
One  minute  later  it  was  52  above  the  normal ;  five  minutes  later  was 
28  above  the  normal,  and  continued  so  for  fifteen  minutes,  when 
another  5  c.c.  was  given.  Three  minutes  after  this,  another  5  c  c. 
During  the  next  six  or  seven  minutes  pressure  was  30  to  40  above 
the  normal ;  it  then  began  to  fall,  the  fall  being  accelerated  by  a 
further  injection  of  10  c.c,  followed  by  death  in  three  minutes,  from 
cardiac  arrest. 
Experiment  5. — Dog;  weight,  8-5  kilos. 
Injected  into  the  jugular  10  c.c,  given  slowly;  one  minute  later, 
pressure  up  to  10  mm.;  10  c.c.  given;  pressure  immediately  rose  15 
mm.,  and  stayed  so  for  three  minutes.  Two  minutes  later  pressure 
at  6  mm.  above  the  normal,  remaining  so  for  another  minute,  when 
it  fell  to  the  normal,  and  10  c.c  was  given.  One  minute  later,  there 
being  no  rise  of  pressure,  another  10  c.c.  was  given.  Pressure  for 
the  next  twelve  minutes  after  this  vas  from  to  to  15  above  the 
