Am"  ju'iyjsge™'}    Acetanilid  in  Synthetical  Remedies.  389 
is  held  out  as  a  medicine,  has  been  represented  under  oath,  by  the  druggists  who 
manufacture  it,  as  containing  the  chemical  principles  of  diastase,  dextrin  and  mal- 
tose in  such  strength  as  would  produce  nausea  if  it  should  be  used  as  a  beverage  ; 
this,  and  other  like  extracts  of  malt  held  out  as  medicines  and  not  as  beverages, 
are  not  regarded  as  medicines  until  facts  brought  before  this  office  show  that 
they  belong  in  the  class  of  malt  beverages  (liquor)  referred  to  in  Section  3,339, 
Revised  Statutes.  Meanwhile,  druggists  who  sell  them  in  good  faith,  as  medi- 
cines only,  are  not  to  be  called  upon  to  pay  special  taxes  as  dealers  in  malt 
liquors  on  account  of  such  sales. 
THE  DETECTION  OF  ACETANILID  IN  SOME  CLOSELY 
RELATED  SYNTHETICAL  REMEDIES.1 
By  Frank  X.  Moerk. 
The  synthetical  remedies  embraced  in  this  investigation  are  either 
immediate  derivatives  of  anilin,  C6H5NH2,  as 
Acetanilid  C6H5NH(COCH3) 
Bxalgin  (methyl-acetanilid)  C6H5N(CH3)(COCH3) 
or  of  para-oxyanilin,  better  known  as  para-amido-phenol.  Of  this 
the  methyl-ether  is  called  anisidin,  the  ethyl-ether  phenetidin 
(their  relation  to  each  other  and  to  their  medicinally  important 
derivatives  is  best  seen  from  their  formulas) : 
Para-amido-phenol   C6H4(OH)NH2 
Anisidin  C6H4(OCH3)NH, 
Phenetidin    .  .  C6H4(OC2H5)NH2 
Methacetin  (acet-para- anisidin)  C6H4(OCH3)NH(COCH3) 
Phenacetin  (acet-para-phenetidin)   C6H4(OC2H5)NH(COCH3) 
Phenocoll  (glycocoll-para-phenetidin)    .  .  .  C6H4(OC2H5)NH(COCH2NH2) 
Lactophenin  (lactyl-para-phenetidin)     .  .  .  C6H4(OC2H5)NH(COCHOHCH3) 
Salophen  (acet-para-amido-phenol  salicylate)  C6H4(C7H503)NH(COCH3) 
Of  these  remedies,  phenocoll  is  the  only  one  used  in  the  form  of 
the  "  hydrochlorate,"  the  free  base  not  being  medicinally  important ; 
the  word  "  phenocoll,"  in  the  following  parts  of  this  paper,  refers  to 
the  important  "  phenocoll  hydrochlorate." 
Of  the  various  tests  that  have  been  published  for  the  detection 
and  identification  of  acetanilid,  none  has  had  the  scope  given  to  it 
which  is  intended  in  this  paper.    Of  these  tests  only  one  is  based 
1  Read  at  the  meetiug  of  the  Pennsylvania  Pharmaceutical  Association,  June 
18,  1896. 
