128 
Production  of  Sulphate  of  Quinine. 
/Am.  Jour,  Pharm. 
\     March,  1885. 
cent.  8'3  per  cent,  being  insoluble  in  water,  appeared  to  be  resin  sol- 
uble in  dilute  alcohol ;  the  remaining  4*3  per  cent,  were  soluble  in 
water  and  were  examined  for  alkaloids.  A  small  quantity  of  crystals 
separated  on  evaporating  the  chloroform  solution  of  this  aqueous  por- 
tion, first  made  alkaline  with  potassium  hydrate.  The  amount,  how- 
ever, was  so  small  that  the  75  grams  of  the  drug  remaining  after 
extracting  the  oil  with  petroleum  spirit  were  exhausted  with  dilute 
alcohol,  the  alcohol  evaporated,  and  the  residue,  after  rendering  alka- 
line, was  shaken  repeatedly  with  chloroform  until  that  solvent  con- 
tained all  the  bitter  principle.  On  evaporating  the  chloroform  a  resi- 
due Avas  obtained  which  all  efforts,  so  far,  have  failed  to  get  in  a  crys- 
talline condition.  It  is  intensely  bitter,  of  a  faintly  alkaline  reaction, 
gives  precipitates  with  phosphomolybdic  acid,  Mayer's  test,  tannic  acid, 
and  gives  off  ammonia  on  heating  with  potassium  hydrate.  It  is 
therefore  quite  certain  that  this  bitter  principle  is  an  alkaloid,  and  we 
suggest  for  it  the  name  of  Lappine. 
The  other  constituents  were  not  determined,  but  they  with  the  bitter 
principle  will  be  further  investigated. 
We  were  induced  to  make  this  analysis  from  an  account  of  the 
medicinal  value  of  the  so-called  burdock  seed  in  Dr.  Squibb's  Ephe- 
meris,''  vol.  i,  page  115. 
Philadelphia,  Feb.  17,  1885. 
Production  of  Sulphate  of  Quinine  in  Europe. — The  note 
under  this  heading  which  was  published  on  page  27  of  the  January 
number  has  been  corrected,  some  time  ago,  in  the  "  American  Oil  and 
Drug  Reporter,'^  as  far  as  it  relates  to  the  production  of  the  factory  of 
Fried.  Jobst,  Stuttgart ;  and  I  now  desire  to  add  that  this  quinine 
factory,  which  for  many  years  has  been  under  my  special  direction, 
does  not,  as  stated  in  the  note  referred  to,  produce  20  kilos  daily,  but 
considerably  more — about  three  times  the  quantity  reported,  as  may  be 
discerned  from  the  fact  that  at  the  European- American  Quinine  Con- 
vention of  the  past  year  the  establishment  of  Fr.  Jobst  ranged  among 
the  four  largest  quinine  factories  of  Europe.  Furthermore,  the  note 
referred  to  requires  a  correction,  since  at  present  the  relations  upon 
this  field  are  completely  altered,  the  leader  of  the  figures  given  on 
page  27,  the  Fabricca  lombarda,  having  retired  from  the  scene  ot 
activity.  O.  Hesse. 
