202 
Alkaloids  from  Remijia  Piirdieana. 
{  Am.  Jour.  Pharm. 
(       April,  1885. 
mass,  readily  soluble  in  water  and  alcohol,  sparingly  soluble  in  chlo- 
roform and  ether.  It  has  an  intensely  bitter  taste,  and  is  a  powerful 
base,  eagerly  absorbing  carbonic  anhydride  from  the  air. 
Methylcinchonamine,  Ci9H23MeN20,  is  prepared  by  boiling  cincho- 
namine  methiodide,  chloride  or  hydroxide  with  caustic  soda.  It  forms 
an  amorphous  white  powder,  melts  at  139°,  is  readily  soluble  in  alco- 
hol, ether  and  chloroform,  insoluble  in  water.  The  chloride  is  amor- 
phous, the  platinochloride,  (Ci9H23MeN20)2,H2PtClg  +  4II2O,  is 
obtained  as  a  reddish  yellow  flocculent  precipitate. 
Cinchonamine  ethiodide,  Ci9H24N20,EtI,  forms  a  colorless  varnish, 
readily  soluble  in  alcohol,  nearly  insoluble  in  water.  The  chloride 
forms  colorless  prisms,  readily  soluble  in  alcohol  and  hot  water.  The 
platinochloride,  (C,9H24N.p,EtCl)o,PtCl4  -f  2II2O,  forms  orange-col- 
ored crystals.  The  sulphate,  (Cj9H24N20Et)2S04,  is  colorless  and  amor- 
phous. The  hydroxide  resembles  the  corresponding  methyl  compound. 
Ethylcinchonamine,  (C,,,H23EtN20)3  +  H2O,  forms  a  white  powder^ 
melts  at  75  to  78°,  or  when  anhydrous  at  140°,  and  is  readily  soluble 
in  ether  and  alcohol.  The  platinochloride,  (Cj9H23EtN20)2,Il2PtClg  + 
3H2O,  forms  a  reddish  yellow  flocculent  precipitate. 
Concusconine,  C23H2gN204  +  H2O. — This  alkaloid  is  obtained  as  the 
normal  sulphate  as  already  described,  and  is  obtained  in  the  free  state 
by  decomposition  of  the  sulphate  with  dilute  soda,  and  recrystalliza- 
tion  from  alcohol  to  which  a  little  ammonia  has  been  added.  It  forms 
colorless  or  pale  yellow  compact  prisms.  It  is  readily  soluble  in  ether, 
chloroform,  and  benzene,  sparingly  soluble  in  boiling  alcohol,  insoluble 
in  water.  It  is  optically  dextrorotary,  giving  for  C23H26N2O4  -f  HgO, 
p.  =  2,  t.  =  15°  ;  in  97  vol  per.  cent,  alcohol  =  40-8°.  The 
hydrate  melts  at  144°,  becomes  anhydrous,  and  then  melts  again  at 
206  to  208°  ;  at  140  to  150°  it  becomes  dark  brown  colored,  being  in 
small  part  converted  into  amorphous  concusconine.  (This  amorphous 
concusconine  is  readily  separated  by  conversion  of  the  fused  mass  into 
the  normal  sulphates,  treatment  with  alcohol  in  which  the  sulphate  of 
the  amorphous  base  is  readily  soluble,  and  precipitation  with  ammonia, 
when  it  separates  in  dark  brown,  amorphous,  readily  fusible  flocks.) 
Concusconine  dissolves  readily  in  acetic  anhydride  apparently  without 
formation  of  an  acetyl-derivative  ;  from  this  it  seems  that  no  hydroxyl- 
groups  are  present.  Nitric  acid  converts  it  into  a  dark  green  mass  ; 
•iddition  of  nitric  acid  to  its  solution  in  acetic  or  hydrochloric  acids 
gives  the  dark  green  coloration  characteristic  of  this  group  of  alkaloids. 
