Therapeutic  Uses  for  Chemicals. 
Am.  Jour.  Pharm. 
January,  1920. 
The  technique  is  as  follows,  the  operation  being  conducted  under 
local  or  general  anesthesia: 
Wound  Preparation. — The  wound  areas  having  previously  been 
thoroughly  cleansed  by  daily  washing  and  shaving,  the  skin  is  thor- 
oughly scrubbed  with  a  solution  consisting  of  2  parts  of  compound 
solution  of  cresol,  10  parts  of  oil  of  turpentine  and  88  parts  of  gaso- 
line, and  then  painted  with  3  per  cent,  tincture  of  iodine. 
Wound  Sterilization.  —  Immediately  after  the  cleansing,  the 
sinuses,  cavities  and  wound  surfaces  are  sterilized  by  the  use  of  the 
solution  of  zinc  chloride,  injecting  it  under  pressure,  or  packing 
with  cotton  pledgets  dipped  in  the  solution,  and  great  care  is  taken 
to  see  that  all  unhealed  and  granulating  surfaces  are  reached. 
Five  minutes  is  allowed  for  the  penetration  of  the  zinc  solution, 
and  if  it  has  been  injected,  under  pressure,  into  bone  sinuses,  a 
tourniquet  must  be  applied  and  the  solution  allowed  to  enter  the 
circulation  only  slowly,  otherwise  collapse  will  result.  Because 
of  the  caustic  character  of  this  solution  and  the  danger  of  direct 
introduction  into  the  circulation  it  cannot  be  used  in  fistulas  con- 
nected with  the  bladder,  or  intestine,  nor  can  it  be  used  in  the  pres- 
ence of  erysipelas,  or  other  acute  spreading  infection. 
Color  Dilineation. — At  the  end  of  five  minutes,  the  following 
solution  is  applied,  in  the  same  manner  as  the  zinc  chloride  solu- 
tion : 
When  this  solution  evaporates  it  leaves  the  exposed  granular 
surfaces  dark  blue-black,  dry,  bloodless  on  manipulation,  and  sterile, 
and  beneath  a  grayish  white  tissue  which  has  been  sterilized  and 
devitalized  by  the  zinc  chloride. 
Excision  of  Infected  Area. — The  entire  diseased  area  is  now  re- 
moved, the  wound  closed,  and  a  moist,  non-irritating,  antiseptic 
dressing  applied  for  the  first  week,  or  until  all  tissue  reaction  has 
subsided.    The  solution  used  consists  of: 
Saturated  Alcoholic  Solution  of  Methylene  Blue 
Potassium  Hydroxide  
Phenol  
Ether,  sufficient  to  make  
100 
3 
5 
Hydrated  Chloral 
Alcohol  
Glycerin  
Saturated  Solution  of  Boric  Acid 
I 
10 
25 
65 
