48 
Guaiacol  Iodide. 
{Am.  Jour.  Pharm. 
January,  1920. 
creosote  is  mixed  in  a  percolator  with  four  or  five  parts  of  freshly 
slaked  lime.  After  the  mixture  has  cooled,  water  is  poured  on  and 
allowed  to  run  through  slowly  until  the  sp.  gr.  drops  below  i.oio, 
when  a  fresh  portion  of  creosote  is  added  and  the  process  repeated. 
The  resulting  solution  of  calcium  creosote  is  a  reddish  yellow  liquid, 
becoming  brown  on  keeping  and  depositing  a  precipitate  of  calcium 
carbonate  on  exposure.  It  has  the  odor  of  creosote,  a  sharp,  peppery 
taste,  an  alkaline  reaction,  and  marked  antiseptic  properties.  It 
contains  the  equivalent  of  about  3  minims  of  creosote  in  each  fluid 
drachm,  and  affords  a  means  for  the  administration  of  creosote  in 
relatively  large  doses  without,  as  a  rule,  producing  intolerance. 
GUAIACOL  IODIDE:  AN  ORGANIC  IODINE  COMPOUND.i 
A  combination  of  guaiacol  and  iodine  is  recommended  by  J. 
Maberly  {Med.  Jour.  S.  Africa,  14:367  (Feb.),  1919)  as  a  convenient 
means  for  the  administration  of  iodine  in  organic  combination.  This 
is  prepared  according  to  the  following  formula: 
Guaiacol,  pure   i  minim.' 
Solution  of  Iodine  (12I/2  grs.  in  one  ounce  S.  V.  R.)   i  minim. 
Rectified  Spirit   20  minims. 
Distilled  Water  to  60  minims. 
The  drugs  are  mixed  in  the  order  given  above,  a  slight  rise  of 
temperature  taking  place  on  the  addition  of  the  water.  The  free 
iodine  disappears  and  a  stable  compound  is  formed  in  which  the  iodine, 
or  a  portion  of  it,  replaces  hydrogen  in  the  guaiacol.  One  drachm 
of  guaiacol-iodide  solution  prepared  as  above  represents  0.026  grain 
(about  V40  grain)  of  iodine. 
The  dose  of  this  solution  is  one  drachm,  mixed  with  an  equal 
quantity  of  simple  syrup  and  two  drachms  or  more  of  water.  Maberly 
recommends  its  use  in  all  cases  in  which  iodine  internally  is  indi- 
cated, such  as  glandular  enlargements,  etc.  The  dose  is  suitably 
reduced  in  the  case  of  children. 
^  From  The  Prescriher,  December,  1919. 
