lyo  Suggestions  for  National  Formulary.     {^"^  MaJ-ciT^^iyTo. 
This  resin  precipitation  method  is  not  all  that  could  be  desired 
since  it  consists  of  the  precipitation  of  a  partially  water-soluble 
resin  by  water,  and  therefore  the  results  are  low.  A  much  more 
accurate  and  consistent  method  is  the  "shake  out"  method  proposed 
for  Fluid  Extract  Podophyllum  by  W.  M.  Jenkins  in  The  Journal  of 
Industrial  and  Engineering  Chemistry,  p.  671,  19 14.  This  "shake 
out"  method  gives  higher  results  than  the  precipitation  method, 
because  total  results  are  obtained  and  the  resultant  resin  answers 
all  U.  S.  P.  requirements  for  Resin  Podophyllin. 
A  perfectly  satisfactory  standard  is:  17  per  cent,  resin.  This 
standard  is  based  upon  practical  attainment,  and  the  trad^  is  fa- 
miliar with  an  extract  of  this  strength. 
FLUID  EXTRACTvS. 
FLUID  EXTRACTS  FOR  WHICH  NO  PRACTICAL  CHEMICAL  OR  PHYSIO- 
LOGIC METHODS  OF  STANDARDIZATION  ARE  AVAILABLE. 
Standards  based  upon  the  average  amount  of  soluble  matter  ex- 
tracted from  the  drug  by  the  menstruum  should  be  adopted  in  order 
to  establish  uniformity  in  market  supplies.  These  standards  con- 
stitute the  famihar  "extractive  standards,"  and  no  difficulty  should 
be  experienced  by  the  Revision  Committee  in  obtaining  satisfactory 
data  for  the  establishment  of  these  standards,  from  the  laboratories 
of  pharmaceutical  manufacturing  companies  who  practice  scientific 
control  of  manufacture  and  also  from  other  scientific  sources. 
Extract  Chirata. — There  is  practically  no  demand  for  this  product 
and  deletion  is  suggested  or  continuance  in  the  next  edition  by  name 
only  and  reference  to  the  present  edition. 
Fluid  Extract  Conium. — The  substitution  of  sulphuric  acid  for 
the  acetic  acid  of  the  present  fox'mula  and  direct  percolation  to  yield, 
is  to  be  recommended. 
The  use  of  2^/4  per  cent,  of  a  10  per  cent,  solution  of  sulphuric 
acid  has  been  found  superior,  in  practice,  to  the  acetic  acid  now 
prescribed,  as  the  sulphuric  acid  is  not  volatile  and  holds  the  alkaloid 
in  solution  more  efficiently.  Slow,  careful,  direct  percolation  to 
yield  gives  practical  exhaustion  when  acetic  acid  is  used,  as  any 
alkaloid  extracted  by  extra  percolation  will  be  largely  lost  when  the 
extra  percolate  is  concentrated  in  preparation  for  its  addition  to  the 
bulk  of  the  percolate. 
When  sulphuric  acid  is  employed,  extra  percolation  may  be 
