172  Suggestions  for  National  Formulary.     {^"-  Ma?ch!V92o: 
Fluid  Extract  Kola. — Standardization  is  to  be  recommended  for 
this  product,  so  as  to  establish  uniformity  in  market  suppUes. 
The  assay  method  for  caffeine  in  Fluid  Extract  Guarana  U.  S.  P. 
is  also  applicable  to  the  assay  of  this  fluid  extract. 
A  standard  of  0.9-1.1  Gms.  caffeine  per  100  Mils,  is  satisfactory, 
because  it  is  based  upon  practical  attainment  and  is  familiar  to  the 
trade. 
Fluid  Extracts  Matico,  Mezerium  and  Quercus. — Deletion  of  these 
fluid  extracts  is  suggested.  The  remarks  under  Fluid  Extract 
Chirata  also  apply  to  these  fluid  extracts. 
Fluid  Extract  Sanguinaria. — Standardization  is  to  be  recom- 
mended in  order  to  establish  uniformity  in  market  supplies. 
The  following  assay  process  has  rendered  excellent  service  for 
purposes  of  standardization: 
Place  exactly  5  Mils,  of  Fluid  Extract  Sanguinaria  on  10  Gms. 
of  oak  sawdust.  Allow  to  dry  spontaneously  in  a  warm  place. 
Place  the  impregnated  sawdust  in  a  bottle.  Add  100  Mils,  of  ether 
and  10  Mils,  of  10  per  cent,  ammonia  water.  Shake  the  bottle  and 
contents  for  four  hours.  Filter  off  an  aliquot.  Shake  out  with  i 
per  cent,  sulphuric  aid.  Make  aci^"  extractions  alkaline  with  10 
per  cent,  ammonia  water  and  extinct  with  ether.  Evaporate  ether 
extractions,  dry  residue  at  80°  C.  and  weigh  as  alkaloids. 
Standard:    2.5  Gms.  alkaloids  per  100  Mils. 
This  standard  is  based  on  practical  attainment,  and  the  trade  is 
perfectly  familiar  with  fluid  extract  of  this  strength. 
The  assay  process  described  above  is  the  typical  "immiscible 
solvent  gravimetric  alkaloidal  assay"  process.  The  only  specific 
feature  is  the  use  of  i  per  cent,  sulphuric  acid  solution  for  extrac- 
tion; weaker  acid  may  be  used,  but  2  per  cent,  acid  results  in  pre- 
cipitation of  alkaloidal  sulphate  which  greatly  interferes  with  drawing 
the  acid  extractions  off  from  the  separator. 
SYRUPS. 
Syrup  lodotannin. — An  assay  for  iodine  is  desirable,  because  it 
is  necessary  to  use  heat  in  the  preparation  of  this  syrup,  while  the 
iodine  is  still  in  a  free  condition.  A  standard  for  iodine  content  will 
insure  uniformity  in  market  supplies  of  this  syrup. 
