252  Purified  Cresol  {Cresylic  Acid).       {^"'- ^  wifY92'S 
CRESOIv. 
Wt.  of  Animal.  Dose  per  Kilo.  Result. 
0.572  0.6  Recovered 
0.61 1  0.6  Recovered 
0.577  07  Died 
o .  640  o .  7  Died 
0.572  0.8  Died 
o .  43  7  0.5  Recovered 
0.480  0.5  Recovered 
o .  446  o .  6  Died 
o .  480  o .  6  Died 
0.570  0.6  Died 
0.340  0.7  Died 
Toxicity  about  90  per  cent,  of  that  of  phenol:  Worth  Hale,  Hyg.  Lab,, 
Bulletin  88;  James  Leake  and  Hugh  B.  Corbin,  Hyg.  Lab.,  Bulletin  no. 
Germicidaiv  Assay. 
Sample  Purified  cresols. 
Method  A.  P.  H.  A.  phenol  coefficient  method. 
(Committee  Report,  Am.  J.  Pub. 
Health,  8  (1918),  506.) 
Organism  B.  typhosus. 
DILUTIONS.  time;  and  RieSUIvTS. 
Sample.  5  10  15  20 
1-300  —  —  —  — 
1-350  —  —  —  — 
1-400  +  —  —  — 
1-450  +  +  —  — 
1-500  +  +  +  + 
Phenol 
i-ioo        ^       —  —  —  — 
i-iio  +  —  ■ —  — 
1-120  +  +  —  — 
1-130  +  +  +  + 
1-140  +  +  +  + 
Coefficient  3.6. 
The  cost  of  the  process  is  inconsiderable,  since  no  complicated 
chemical  or  mechanical  steps  are  necessary.  It  is  evident  from 
observation  of  the  steps  in  the  process  that  no  unusual  equipment 
is  needed  and  only  the  commonest  chemicals  are  employed.  It  is 
evident,  therefore,  that  here  again  the  German  chemists  profited  at 
our  expense  for  many  years  while  the  crude  materials  waited  only 
for  proper  development. 
The  logical  place  for  the  economical  production  of  the  refined 
cresols  is  where  the  crude  material  is  first  separated  from  the  oils 
