'^"'■-^''May^YS:!    Pharmacology  of  Cotton  Root  Bark.  291 
disturbing  change  is  such  as  may  be  seen  in  experiment  788, 
where  there  is  for  some  little  time  a  slight  but  gradual  fall 
in  pressure,  and  in  779,  where  there  is  a  slight  but  gradual 
rise.  In  both  cases,  however,  the  pressure  ran  with  fair  uni- 
formity after  the  10  minute  period.  In  experiment  767  a 
slight  rise  appears  after  the  20  minute  period.  No  cause  can 
be  assigned  for  these  changes  except  by  supposing  that  the 
force  or  rate  of  the  respiration  was  not  such  as  to  quite  ac- 
commodate the  needs  of  the  particular  animals.  These  points 
should  be  considered  when  viewing  Table  6,  6A  and  6B,  which 
show  the  results  of  blood  pressure  experiments  cn  cotton  root 
bark.   Three  of  the  kymograms  may  be  seen,  also,  in  Chart  1. 
Table  4  Records  of  Normal  Blood  Pressures  of  Dogs 
(Morphine-Hyoscine  Anaesthesia) 
Pressure  ^iven  in  millimeters 
Kymograms 
767 
773 
788 
775 
779 
786 
Time 
Dog 
Dog 
Dog 
Dog 
Dog 
Dog 
10.2  Kg. 
8.3  Kg. 
11.6  Kg. 
6.2  Kg. 
19.3  Kg. 
10  Kg. 
Start 
110 
119 
148 
125 
104 
123 
5' 
108 
120 
138 
115 
117 
120 
10' 
110 
127 
135 
106 
127 
117 
15' 
110 
124 
132 
105 
133 
114 
20' 
109 
125 
130 
105 
133 
120 
25' 
116 
122 
130 
105 
134 
animal 
30' 
116 
122 
129 
106 
135 
moved 
35' 
119 
118 
127 
119 
134 
141 
40' 
122 
117 
126 
134 
139 
45' 
122 
118 
126 
134 
135 
50' 
122 
118 
128 
134 
55' 
120 
114 
127 
138 
60' 
118 
116 
138 
65' 
115 
115 
138 
70' 
113 
115 
75' 
112 
118 
80' 
109 
100' 
111 
115' 
107 
A  few  blood  pressure  tracings  were  made,  showing  the 
effect  of  ergot,  in  order  to  compare  the  action  of  cotton  root 
bark  with  that  of  ergot  on  the  circulation,  and  to  show  how 
extensively  the  normal  pressure  may  be  influenced.  Table  5 
shows  the  results  of  six  ergot  blood  pressure  experiments  and 
gives  one  a  fair  idea  of  the  great  elevation  in  pressure  which 
is  almost  invariably  produced  by  carefully  prepared  fluidex- 
tracts  of  this  drug. 
Table  5 
Blood  Pressure  Records  on  Samples  of  Fluid  Extract  of  Erogt,  Taken  on  Dogs 
Dog  Wt. 
Dose 
Normal 
Pressure  at  Periods  After  Injection  of  Drug 
1-3'      5'       10'      15'      20'      25'  30' 
in  Kg. 
per  Kg. 
Pressure 
12.7 
.05  c.c. 
147 
225 
218  187 
187 
185     178  174 
10.6 
.05  c.c. 
147 
237 
226  206 
195 
189     188  185 
14.4 
.05  c.c. 
150 
214 
214  200 
176 
167  (150at42') 
6.6 
.10  c.c. 
144 
263 
220  204 
190 
188  181 
10.5 
.10  c.c. 
129 
175 
198  190 
184 
182  180 
22.2 
.10  c.c. 
144 
190 
172  220 
234 
220     216  210 
