294  Pharmacology  of  Cotton  Root  Bark.     {^"'-  ^  M^ay^^™. 
Table  6 
Blood  Pressure  Records  of  Thirteen  Samples  of 
Cotton  Root  Bark  on  Dogs 
Dose       Pressure    Pressure  at  Periods  After  Injection 
Drug  per  Kg.      at  Start      1-3'     5'     10'     15'    20'    25'  30 
vKymogram  759.   Dog  Wt.  5.5  Kg.   Morphine  S.-Hyoscine  HBr.) 
Cotton  R.  No.  10      .1   c.c.         134         143    130    132    129    126  120 
.2   c.c.         120         136    128    127    131    129  127 
F.  E.  Ergot  .05  c.c.         127         158    145    148    145    154  157 
(Kymogram  763.    Dog  Wt.  11.8  Kg.    Morphine  S.-Hyoscine  HBr.) 
CottonR.No.il      .1   c.c.         114         125    120    117    123    120  123 
.2   c.c.         123         132    124    121    118    118  122 
F  E.  Ergot  .05  c.c.         122         140    138  136 
 .1   c.c.         136         157    133    124  121  
(Kymogram  764.    Dog  Wt.  11.2  Kg.    Morphine  S.-Hyoscinc  IJ  Br. ) 
Cotton  R.  No.  12      .1    c.c.  112  123    135    120    120    120  117 
.2   c.c.         117         127    123    126    117  117 
F.  E.  Ergot  .05  c.c.         118         172    170    169    152  140 
 .1    c.c.  127  147    137  11'^  
(Kymogram  765.    Dog  W  t.  8.9  Kg.    Morpiiine  S.-Hyoscine  HBr.) 
Cotton  R.  No.  13      .1   c.c.         116         124    129    128    133  133 
.2   c.c.         133         147    141    137    137  133 
F.  E.  Ergot  .05  c.c.         116         140  140  
Drug 
(Kymogram  902. 
F.  K.  C.  (Dry) 
4')'  later  = 
Table  6-A 
Blood  Pressure  Records 
of  Commercial  Cotton  Root  Bark  on  Dogs 
Pressure  at  Periods 
Dose       Pressure  After  Injection 
per  Kg.      at  Start      1-3'    5'     10'     15'    20'  25' 
Dog  Wt.  4.7  Kg.    Morphine  Sulphate  Anesathesia.) 
.1    c.c.  144         160    145    143  134 
.1    c.c.  106  126    118  117 
Dog  Wt.  10  Kg.  Morphine  Sulphate  Anaesttiesia.) 
.1    c.c.  110         138    136    127    120  120 
.15  c.c.  120         147    134    136    136  136 
 .20  c.c.         136         138  122    134  131 
Dog  Wt.  11.8  Kg.    Morphine  Sulphate  Anaesthesia.) 
.15  c.c.  136  144 
.15  c.c.  136  136 
.15  c.c.  143         159    145  145 
.20  c.c.  145         158    122    141  140 
.15  c.c.  140         178    170    158    158    151  149 
.15  c.c.  Caused  death 
(Kymogram  901. 
F.  E.  C.  (Dry) 
(Kymogram  900. 
Alcohol-glyc. 
(3  to  1) 
F.  E.  C.  (Dry) 
F.  E.  Ergot 
F.  E.  C.  (Dry) 
(Kymogram  894. 
Alcohol-glyc. 
F.  E.  C.  (Dry) 
F.  E.  Ergot 
Dog  Wt.  12  Kg.  Morpnine  Sulphate  Anaestiiesia.) 
.2   c.c.  Ill  119 
.2  c.c.  118  128  119  120  114 
.2   c.c.  123         114    clot  124 
(Kymogram  893. 
Adrenal  Ext. 
F.  E.  C.  (Dry) 
Dog  Wt.  10  Kg.   Morphine  Sulphate  Anaesthesia.) 
116         146  130 
138    114  110 
115    clot    112  95 
110    101  101 
Fall     Slow  recovery. 
,1  c.c. 
.15  c.c. 
.2  c.c. 
.3  c.c. 
116 
129 
110 
103 
101 
(Kymogram  891. 
Adrenal  Ext. 
F.  E.  C.  (Dry) 
F.  E.  Ergot 
Dog  Wt.   7  Kg.  Morphine  Sulphate  Anaesthesia.) 
135         157    143  143 
.2   c.c.  143         164    143  140 
.2   c.c.  139         150    120    117    123  126 
.2  c.c.  126         136    124    127  127 
.3   c.c.  Gradual  fall  for  5'  then  slow  recovery. 
.15  c.c.  Fall,  slight  rise,  then  gradual  lowering. 
