296 
Pharmacology  of  Cotton  Root  Bark. 
lAm.  Jour.  Pharm. 
1  May,  1920. 
Drug 
(Kymogram  890. 
Adrenal  Ext. 
Alcohol-glyc. 
F.  E.  C.  (Dry) 
F.  E.  Ergot 
Table  6-A 
Blood  Pressure  Records 
of  Commercial  Cotton  Root  Bark  on  Dogs 
Pressure  at  Periods 
Dose       Pressure  After  Injection 
per  Kg.      at  Start      1-3'    5'     10'     15'  20' 
Dog  Wt.  8.6  Kg.   Morphine  Sulphate  Anasethesia.) 
143         170  140 
No  effect 
146  155  128  126  clot 
122  140  84  93  clot 
Slight  rise,  then  gradual  fall. 
.3  c.c. 
.2  c.c. 
.3  c.c. 
.15 
132 
102 
c.c. 
(Kymogram  892.   Dog  Wt.  27.4  Kg. 
F.  E.  C.  (Green)            .2  c.c. 
F.  E.  Ergot  .1  c.c. 
Morph.  S.-Atropine  S.) 
143  154    146    146    142  144 
144  210    210    204    200  202 
25' 
122 
107 
(Kymogram  691.   Dog  Wt.  10.8  Kg.    Morph.  S.-Hyoscine  HBr.) 
After  Ergot. 
F.  E.  C.  (Dry)  .05  c.c.         125         135    130    128    125    123  122 
(Kymogram  982.   Dog  Wt.  11  Kg. 
F.  E.  C.  (Green)  .2  c.c. 
Ale. -glycerin  .2  c.c. 
F.  E.  Ergot  .05  c.c. 
F.  E.  C.  (Green)  .2  c.c. 
Morph.  S.-Hyoscine  HBr.  Cut  Vagi.) 
122         144    126  127 
No  effect 
132         190    163    156    135  130 
No  effect 
(Kymogram  895.   Dog  Wt.  2.7  Kg.  Morph.  S.-Atropine  S.) 
F.  E.  C.  (Green)            .2   c.c.  112         134    132    132  134  134  130 
.2   c.c.  130         148    124    124  118  112  112 
F.  E.  Ergot                   .1   c.c.  112         154    138    131  120  119  119 
Table  6-B 
Blood  Pressure  Records 
of  Commercial  Cotton  Root  Bark  on 
Spinal  Preparations 
Pressure  at  Periods 
Dose 
Drug  per  Kg. 
(Kymogram  896.   Preparation  Wt. 
F.  E.  C.  (Dry)         .2  c.c. 
F.  E.  Ergot  .2  c.c. 
F.  E.  C.  .2  c.c. 
Pressure 
at  Start  1-3' 
2.2  Kg.   Cat.)  • 
82  46-69 
17  38-138 
Abrupt  fall. 
After  Injection 
5'     10'     15'  20' 
25' 
62  67 
134  126  110  100  78 
Heart  stopped.  Epine- 
phrin  was  given  and  the  heart  massaged. 
Heart  began  beating.  Later  ergot 
caused  a  rise  in  pressure. 
(Kymogram  898.  P 
Ale. -give.  (3  to  1) 
F.  E.  C.  (Drv) 
F.  E.  Ergot 
F.  E.  C. 
:ion  Wt. 
2.4  Kg. 
Cat.) 
.16  c.c. 
58 
60 
56 
.16  c.c. 
58 
48 
46 
.08  c.c. 
44 
grad. 
80     75  66 
rise 
.16  c.c. 
64 
Fall. 
Heart  stopped. 
and  epinephrin 
Massag- 
started 
F.  E. 
F.  E. 
.08  c.c. 
.08  c.c. 
mg 
heart. 
Gradual  fall. 
Pressure  fell  nearly  to  zero,  heart 
stopped  but  recovered  after  massaging 
and  epinephrin.   
(Kymogram  4015. 
F.  E.  C.  (Dry) 
F.  E.  Ergot 
F.  E.  C. 
F.  E.  Ergot 
Pit.  Ext.  1:1000 
Dog  preparation  Wt.  7.4  Kg.) 
.10  c.c. 
65 
70-63 
56 
.05  c.c. 
51 
65-62 
66 
.10  c.c. 
60 
62-59 
56 
.10  c.c. 
55 
63-58 
60 
.20  c.c. 
60 
63-67 
51 
65 
61  60 
