304 
U.  S.  P.  IX  Revision. 
Am.  Jour.  Pharm. 
May,  1920. 
a  few  cases.  In  general  the  results  by  this  method  were  rather  indefi- 
nite and  unsatisfactory,  and  no  decided  difference  could  be  detected 
between  any  of  the  samples  tested. 
A  very  slight  and  transient  pressor  effect  was  produced  on  the 
blood  pressure  of  the  dog.  On  the  intact  cat  a  depressor  effect  or 
no  effect  at  all  was  observed.  On  the  cat  spinal  preparation  a  de- 
pressor effect  was  observed,  and  on  a  dog  spinal  preparation  a  pressor 
followed  by  depressor.  By  this  method  no  decided  difference  could 
be  noticed  between  any  of  the  samples  tested. 
Rather  large  doses  produced  small  contractions  of  the  isolated 
guinea  pig  uterus  and  the  uterus  of  the  cat  and  rabbit  in  situ.  By 
the  uterus  methods  only  samples  of  commercial  drug  were  tested. 
No  decided  difference  could  be  noticed  between  any  of  these  from  the 
results  obtained. 
By  the  four  methods  employed,  the  activity  shown  by  cotton  root 
bark  was  not  comparable  to  that  possessed  by  ergot. 
Tables  of  results  and  charts  of  tracings  are  given. 
1  wish  to  express  my  obligations  to  Dr.  A.  L.  Walters  under  whose 
supervision  this  work  was  carried  out. 
Credit  is  due  Mr.  C.  E.  Lawson,  for  preparing  the  thirteen  ex- 
perimental samples,  and  Mr.  C.  C.  Hargreaves  and  Mr.  E.  E.  Swan- 
son  for  assistance  in  carrying  out  the  experiments. 
References. 
^  Scott,  Therapeutic  Gazette,  35:  162,  191 1. 
2  Sherrington,  Journal  Physiology,  38:  375. 
3  Power  and  Brownhifr.  Pharmaceutical  Journal,  93:  420-423. 
Research  Department, 
Eli  Lilly  &  Company, 
Indianapolis,  Indiana. 
THE  MACHINERY  FOR  THE  U.  vS.  P.  IX  REVISION.* 
By  E.  Fullerton  Cook,  Ph.M. 
philadelphia,  pa. 
GENERAL  COMMITTEE  OF  REVISION. 
The  General  Committee  of  Revision,  consisting  of  51  members, 
one  of  whom  was  the  President  of  the  Convention,  ex-officio,  having 
been  elected  by  the  Pharmacopoeial  Convention  of  19 10,  the  com- 
*  Read  before  the  Philadelphia  Branch  of  the  American  Chemical  Associa- 
tion. 
