^Sptember^^92oJ  United  States  Pharmacopoeial  Revision.  641 
neither  necessary  nor  practicable  to  use  a  freshly  prepared  product 
except  for  intravenous  or  intramuscular  injections. 
Liquor  Sodii  Chloridi  Physiologicus . — In  the  sterilization  of  this 
preparation,  boiling  is  permitted  for  at  least  one  hour,  but  no  men- 
tion is  made  of  the  fact  that  if  such  a  process  is  used,  the  evaporated 
water  must  be  replaced  by  sterilized,  freshly  distilled  water.  Such 
a  statement  should  be  inserted,  and  the  operator  directed  to  simul- 
taneously prepare  sufficient  sterilized,  distilled  water  in  a  second 
flask.  In  stopping  the  flask,  it  is  desirable  to  place  a  piece  of  sterile 
gauze  under  the  cotton  plug. 
The  statement  is  made  that  this  solution  should  not  be  •  used 
after  it  has  been  made  forty-eight  hours.  This  should  be  followed 
by  the  phrase,  "if  it  is  to  be  used  for  intravenous  injections." 
Why  should  sterilized  distilled  water  be  boiled  for  one-half 
hour  and  this  preparation  for  one  hour  to  insure  sterile  end  products? 
For  the  sake  of  uniformity,  the  time  directed  should  be  the  same  in 
each  case. 
Virus  Vaccinicum. — ^Mention  is  made  that  the  pulp  is  rubbed 
up  into  a  smooth  emulsion  with  glycerin.  It  might  be  well  to  state, 
"with  sufficient  glycerin  to  cause  it  to  conform  to  the  established 
standard." 
Blood  Coagulants. — ^There  is  a  large  demand  for  a  good  blood 
coagulant.  A  method  of  preparing  such  a  product,  together  with  a 
method  for  its  standardization  should  be  introduced  into  the  next 
U.  S.  P. 
Beef  Extracts,  page  527. — ^Why  should  the  U.  S.  P.  refer  to  Lie- 
big's  or  any  other  make?  It  is  true  that  this  make  is  very  satis- 
factory, but  the  Pharmacopoeia  should  not  name  any  specific  manu- 
facture. 
RKAGENTS,  TEST  SOLUTIONS,  HTC. 
Culture  Media. — If  retained,  a  more  comprehensive  list  should 
be  included.  Methods  for  determining  reactions  or,  if  advisable, 
the  hydrogen-ion  value  of  these  products  should  be  added. 
Sterilization. — A  page  and  a  half  is  devoted  to  the  exceedingly 
interesting  and  important  subject  of  sterilization.  A  more  intensive 
and  instructive  chapter,  giving  the  specific  details  of  procedure 
should  be  provided.  As  it  is  at  present,  it  is  of  little  value  and  might 
as  well  be  deleted. 
