712 
Action  of  Adonis  Vernalis. 
Am.  Jour.  Pharm. 
October,  1920. 
This  shows  an  increase  in  the  duration  of  both  systole  and  dias- 
tole at  first;  the  diastole  being  greatly  increased  in  the  later  stages, 
while  the  systole  is  not  quite  so  prolonged. 
The  effect  of  adonis  on  the  peripheral  blood  vessels  was  determined 
by  perfusing  dilute  solutions  through  the  peripheral  circulations  of 
Tracing  4-B. 

'ifit^i)lf||[I|j|(!l|l((f(|![((|f||l(j(|^^^ 
((l(ll(|(|jif[f[ftlfl|||[j|j)ll( 
llilllillllilllllilllllillllllllii^ 
Tracing  4-C. 
Tracing  4- A.  Shows  the  increased  outflow  from  the  venous  cannula  imme- 
diately following  the  administration  of  0.3  cc.  of  adonis  at  arrow. 
Tracing  4-B.  A  direct  continuation  of  A,  and  shows  a  gradi^al  slowing  of  the 
venous  outflow,  which  becomes  more  marked  in  C. 
frogs  and  rabbits.  (Tracing  4.)  In  frogs  a  cannula  was  placed  in 
the  abdominal  aorta  and  the  drops  recorded  as  they  came  from  the 
median  abdominal  vein.  A  similar  method  was  used  in  rabbits. 
The  results  in  the  two  cases  showed  no  variation.  Ringer's  solution 
was  first  perfused  through,  and  after  a  normal  or  steady  rate  was  ob- 
