732  Samples  of  ''Grey'  Cinchona  Bark.    } ^"'o{?ober^''i92": 
cinchonine  as  quinine,"  and  Delondre  and  Bouchard  found  cin- 
chonine  in  relation  to  quinine  sulphate  in  the  proportion  of  4  to  i. 
From  some  old  records  of  J.  E.  Howard  it  would  appear  that 
on  analysis  a  typical  grey  bark  of  that  period  would  yield  about 
0.45  per  cent,  quinine  sulphate  and  about  0.90  per  cent,  cincho- 
nine alkaloid.  A  parcel  of  thirty-eight  bales,  mark  "D.  F.  C," 
ex.  s.s.  "Cedric,"  was  analyzed  early  this  year,  and  the  authors 
obtained  the  following  results,  which  are  fairly  well  in  keeping  with 
the  references  given  above: 
Quinine  Alkaloid   0.45  percent. 
Cinchonidine  Alkaloid   0.22  " 
Cinchonine  Alkaloid   0.63  " 
Quinidine  Alkaloid   nil 
Amorphous  Alkaloid   0.48  " 
Total  Alkaloid   1.78 
The  selling  analysis  quoted  by  the  merchant  showed  quinine 
0.42  per  cent.,  and  total  alkaloid  1.49  per  cent.,  which  closely  agrees 
with  the  authors'  fuller  separation  of  the  alkaloids  given  above. 
Another  parcel  of  "Loxa"  bark  recently  analyzed,  apparently 
of  the  same  type,  contained  quinine  alkaloid  0.33  per  cent,  and 
cinchonine  alkaloid  0.58  per  cent. 
These  two  recent  parcels  appear  to  conform  to  the  old  jstand- 
ards  of  typical  grey  bark,  and  call  for  no  special  comment,  but 
the  following  large  parcel,  the  details  of  which  are  given  below,  is, 
in  the  authors'  opinions,  unique  in  the  history  of  the  Cinchonaceae. 
In  March,  1920,  we  received  from  the  same  source  a  sample 
of  a  parcel  of  138  bales  of  South  American  cinchona  bark  (marked 
"D  F.  C,"  ex.  s.s.  "Elder  Branch"),  together  with  an  analytical  re- 
port that  it  contained  6  per  cent,  of  alkaloids,  but  only  minute 
traces  of  quinine.  The  sample  was  therefore  submitted  to  a  very 
thorough  examination,  with  most  surprising  results,  which  fully 
bore  out  the  analyst's  statement  above  mentioned: 
Quinine  Alkaloid   0.027  percent. 
Cinchonine  Alkaloid   5  490  " 
Amorphous  Alkaloid   0.785  " 
Total  Alkaloid   6.302  " 
There  were  evidences  of  very  small  quantities  of  quinidine,  but 
apparently  no  cinchonidine  was  present. 
