AZ7nsf^%S: }     Glass  for  Manufacture  of  Ampuls.  583 
tical  conditions  in  ampuls  made  from  the  glass  undergoing  test; 
the  ampuls  having  been  treated  with  dilute  hydrochloric  acid  and 
finally  thoroughly  washed  free  from  acid  and  dried  before  the  alka- 
loidal  solution  is  placed  in  them.  The  preferred  test  is  the  "particu- 
lar" one  which  is  in  all  respects  similar  to  the  "general"  test  except 
that  the  particular  solution  which  is  intended  to  be  marketed  in  the 
ampuls  is  used  in  place  of  the  morphine  sulphate  or  strychnine  sul- 
phate solutions. 
"Spicule  Test." — ^Work  the  glass  into  ampuls.  Place  a  0.6 
per  cent.  NaCl  solution  (or  any  particular  solution)  in  the  ampuls; 
seal  and  sterilize  under  practical  conditions.  The  solution  is  then 
carefully  examined  under  a  magnifying  glass  for  spicules  or  splinters 
of  glass. 
Exact  conformity  with  the  above  test  is  absolutely  necessary 
in  order  to  permit  the  use  of  any  particular  glass  for  the  manufacture 
of  ampuls. 
The  following  tests  are  applicable  for  comparative  purposes  only, 
and  are  occasionally  employed  as  confirmatory  checks : 
" Phenolphthalein  Alkalinity  Test.'' — Treat  the  glass  with  dilute 
HCl  followed  by  very  thorough  washing.  Boil  a  sample  correspond- 
ing to  500  sq.  centimeters  of  surface  for  16  hours  with  distilled  water, 
keeping  the  sample  covered  with  fresh  additions  of  water  as  required. 
Remove  the  glass,  add  i  Cc.  phenolphthalein  test  solution  to  the 
water  in  which  the  glass  was  boiled  and  titrate  to  neutrality.  Make 
a  correction  on  the  water,  vessel  in  which  the  boiling  was  conducted, 
locality  in  which  the  test  was  carried  out,  etc.,  by  running  a  blank 
under  precisely  the  same  conditions  employed  in  making  the  test, 
and  at  the  same  time.  Report  alkalinity  as  milligrams  of  NaOH 
per  100  sq.  cm. 
"Loss  to  Water  Test." — The  sample  used  in  the  "phenolphthalein 
alkalinity  test"  is  weighed  before  and  after  boiling.  Report  loss 
as  milligrams  per  100  sq.  cm. 
"Vulnerability  to  Aklaline  Fluids  Test." — Repeat  the  "loss  to 
water  test,"  using  a  new  sample,  and  using  2  per  cent,  sodium  car- 
bonate solution  in  place  of  water,  keeping  up  the  volume  by  fresh 
additions  of  water  only.    Report  loss  as  milligrams  per  100  sq.  cm. 
"Phenolphthalein  Alkalinity  Autoclave  Test." — Water  containing 
a  few  drops  of  phenolphthalein  test  solution  is  placed  in  the  ampul 
which  has  previously  been  acid-washed  and  thoroughly  rinsed  with 
distilled  water);  the  ampul  is  sealed  and  autoclaved  at  12  lbs.  steam 
