NARCOTINE AS A SUBSTITUTE FOR QUININE. 245 
gland were immensely enlarged, and the case hopeless from 
the beginning. 
Dr. O'Shaughnessy added that, besides the sixty cases now 
recorded, more than one hundred ague patients had been treat- 
ed by his pupils and acquaintance with perfect success by this 
remedy. 
[In a subsequent number of the " India Journal" the fol- 
lowing letter appears, addressed to Dr. O'Shaughnessy, by Mr. 
Green, civil surgeon, Howrah:] — 
" I have now employed the narcotine in sixteen cases of 
remittent fever, and such is my opinion of the efficacy of the 
remedy, that in instances of fever, intermittents and remit- 
tents, in ordinary healthy subjects, and in whom there is no 
complication of severe organic disease, I give it with the full 
expectation of arresting the next periodic return of the fever. 
I have seen this result follow in ten of the cases of the fever 
alluded to. I consider narcotine a more powerful antiperiodic 
than quinine. The remedy does not act silently. I have ob- 
served a degree of general heat follow its use in the first 
instance, and, subsequently, perspiration; so that it appears to 
excite in the system a salutary and powerful counteraction'as 
to stop the morbic concentration that issues in fever. I have 
not observed narcotine to lead to local organic disturbance in 
the cases in which I have used it. In short, even from my 
scanty experience, I consider the remedy an invaluable 
one." 
Indian Journal of Medical Science. 
