ON PHLORIDZINE. 
51 
ART. XI. — EXTRACT FROM A PAPER ON PHLORIDZINE. 
By T. Boullier. 
The author having, in the medical practice of his vicinity, 
perceived great advantages from phloridzine employed as a 
febrifuge, compared with the sulphate of quinine, has been 
occupied with the means of obtaining easily this medicine in 
a state of purity. The following is the method he directs: 
Having procured living roots of the apple tree, recently 
taken from the ground, the bark is to be stripped off and placed 
in a basin of copper, and sufficient water poured upon it to 
cover it entirely. It is to be then boiled, taking care to add, 
from time to time, enough water to replace that which eva- 
porates; after four hour's boiling, the liquid is to be decanted, 
and the same quantity of water, as at first, is to be added 
to the residue, which, having boiled for an hour only, 
is to be decanted. These two products, separated and 
placed at rest during thirty hours, will deposit at the bottom 
of the vessel a large quantity of phloridzine, resembling deep 
red velvet. 
It is necessary, for the second decoction, to divide the bark 
while yet hot, and to beat it in a marble mortar. 
All the phloridzine being put together, half its weight of 
animal charcoal is to be added; and, after having been boiled 
in a suitable quantity of water for some minutes, it is to be 
filtered. It must be thus purified three times, and the last 
time received in a vessel previously heated by boiling water, 
so as to obtain by slow cooling a handsome crystallization, 
which takes place at the end of some hours. 
The whole is to be poured upon a sheet of paper, stretched 
upon a cloth to filter, and allowed to dry at the common tem- 
perature. 
Phloridzine is a light substance of great whiteness, crys- 
tallized in handsome silky needles, without action on test 
paper, or upon the syrup of violets; its taste is slightly bitter, 
but not followed by any astringency. 
