Am.  Jour  Pharm. 
Feb.,  1884. 
Hippurate  of  Soda. 
109 
Dr.  Garrod  says:  "There  is  no  doubt  that  if  hippurate  of  soda  be 
added  to  a  blood  serum  which  shows  the  presence  of  a  urate,  the  latter 
is  soon  removed  from  it." 
I  make  these  preliminary  remarks  merely  to  show  on  what  grounds 
the  introduction  of  this  remedy  is  based.  In  view  of  the  salt  coming 
into  general  use,  I  have  made  a  number  of  experiments  in  regard  to 
its  behavior  towards  other  substances  with  which  it  might  be  admin- 
istered in  combination. 
There  are  only  two  forms  in  which  we  shall  likely  be  called  upon 
to  dispense  it,  namely,  in  powders  and  mixtures,  and  in  regard  to  these 
only  have  I  made  experiments.  Avoiding  details,  I  shall  summarize 
the  results  which  seem  worth  recording. 
(1.)  Powders. — The  hippurate  of  soda  itself,  dispensed  in  powder 
form,  keeps  quite  well  in  paper.  Combinations  of  the  salt  with  lithia 
carbonate  and  citrate  and  bicarbonate  of  potash  and  soda,  put  up  in 
powders  in  the  usual  way  and  kept  for  a  fortnight,  were  found  on 
examination  to  be  in  as  good  condition  as  when  prepared. 
(2.)  Mixtures. — Like  all  alkaline  salts,  the  taste  of  hippurate  of 
soda  is  disagreeably  saline.  I  have  tried  a  number  of  combinations 
with  the  object  of  rendering  its  administration  as  pleasant  as  possible, 
and  the  results  may  be  briefly  stated. 
Chloroform  water  or  spirit  of  chloroform  seems  to  make  it  more 
disagreeable,  rendering  it  almost  nauseous. 
Infusion  of  calumba  disguises  the  saline  taste,  and  where  the  bitter 
is  not  an  objection,  affords  an  eligible  vehicle. 
The  most  agreeable  mixtures,  however,  are  obtained  by  employing 
syrup  and  j^eppermint  water,  or  glycerin  and  cinnamon  water. 
The  following  examples  may  suffice  : 
(1.)    R  Sodse  hippurat.           .         .         .         .  gr.  80 
Lithise  carb.          .         .         .         .  gr.  24 
Glycerin.          .....  £iv 
Aq.  cinnam.          ....  ad  §viij 
M.    Sig.    One-eighth  part  for  a  dose. 
(2.)    R  Sodee  hippur.         .         .         .         .  3ij 
Potass,  citrat.     .....  3iij 
Syrupi         ......  3yj 
Aq.  menth.  pip.          .         .         .  ad  £vj 
M.    Sig.    Tablespoonful  for  a  dose. 
The  addition  of  an  alkaline  carbonate  or  citrate  as  given  in  the 
