Citrate  of  Iron  and  Quinine.  317 
Sample  No.  1  was  obtained  in  the  original  bottle,  and  judging  from 
its  behavior  was  made  very  nearly  in  accordance  with  the  Pharma- 
copoeia. It  contained  no  ammonia  and  dissolved  slowly  in  cold  water. 
Chloroform  extracted  *557  Gm.  of  soluble  matter,  which  after  being 
treated  as  described,  weighed  '470  Gm.  or  11*25  per  cent,  of  alkaloid. 
The  only  noticeable  difference  between  this  sample  and  the  U.  S. 
Pharmacopoeia  preparation  was  in  the  straw  yellow  color  of  the  alkaloid. 
No.  2,  obtained  in  the  original  bottle,  was  in  thin  yellowish  brown 
scales,  which  dissolved  quickly  in  cold  water,  and  on  heating  with 
potassa  gave  off  ammonia.  Chloroform  left  a  residue  of  *493  Gm. 
which  after  further  treatment  weighed  *385  Gm.  or  9*625  per  cent. 
This  residue  had  a  dark  brown  color,  and  was  resinous  in  appearance 
and  fracture. 
No.  3  was  obtained  in  bulk  from  a  retail  store.  It  contained 
ammonia,  and  in  appearance  resembled  No.  2.  The  chloroform  residue 
weighed  *515  Gm.  and  on  treating  this  further  yielded  the  alkaloid 
similar  to  that  of  No.  2  and  weighing  *375  Gm.  or  9.375  per  cent. 
No.  4  was  also  purchased  from  the  shop  bottle  of  a  retail  store.  It 
contained  ammonia,  and  like  the  two  previous  samples  was  in  thin 
yellowish  brown  and  easily  soluble  scales.  Chloroform  removed  *485 
Gm.  and  the  final  residue  weighed  *380  Gm.  or  9*5  per  cent.  The 
alkaloid  was  dark  brown  and  resinous. 
No.  5,  from  an  original  bottle,  was  in  very  thin  yellowish  red,  and 
very  easily  soluble  scales  containing  ammonia.  Chloroform  extracted 
*508  Gm.  and  the  alkaloid  obtained  weighed  *410  Gm.  or  10*25  per 
cent.  This  alkaloid  was  not  as  dark  colored  as  Nos.  2,  3  and  4,  but 
was  resinous  in  fracture. 
No.  6  was  obtained  in  bulk,  and  like  No.  5  was  in  very  thin  scales, 
and  proved  to  be  an  ammonio  citrate.  The  chloroformic  residue  weighed 
•511  Gm.  and  this  after  the  final  treatment  weighed  *385  Gm.  which 
was  9*625  per  cent. ;  it  resembled  that  of  No.  5. 
It  would  appear  from  these  results,  that  owing  to  the  demand  for  an 
easily  soluble  salt,  the  manufacturers  put  chiefly  an  ammonio  citrate 
on  the  market,  as  five  out  of  six  of  my  samples  contained  ammonia. 
The  final  residue  of  alkaloids  from  these  five  samples  were  nearly 
of  the  same  dark  appearance,  somewhat  resembling  chinoidin,  and  due 
probably  to  the  use  of  unbleached  or  amorphous  alkaloids  in  place  of 
the  pure,  white  quinine  directed  to  be  used  in  the  Pharmacopoeia. 
Neither  of  the  samples  left,  on  incinerating,  an  ash  of  an  alkaline  re- 
Am.  Jour.  Pharm. 
June,  1884. 
