Am.  Jour  Pharm. 
June,  1884. 
Morphine. 
335" 
the  diacetyl  compound.    The  yield  is,  however,  very  bad,  a  much 
more  satisfactory  result  being  obtained  with  morphine  methochloride. 
Diacetylmorphine  methochloride  crystallizes  in  concentrically  grouped 
needles,  which  are  easily  soluble  in  water,  and  give  no  coloration  with 
ferric  chloride.  From  its  solutions  potassium  iodide  precipitates  diacetyl- 
morphine methiodide.    The  chloride  yields  a  pale  yellow  platinochloride 
crystallizing  in  small  needles  containing  1  mol.  H20,  which  they  partly 
lose  on  exposure  to  the  air,  completely  at  110°.    The  action  of  methyl 
iodide  on  morphine  in  the  presence  of  bases  has  already  been  studied  by 
Grimaux("Am.  Jour.  Phar.,"  1881,619).  With  acetic  anhydride  codeine 
(methylmorphine)  gives  acetylcodeine  crystallizing  from  ether  in  prisms 
which  melt  at  133°.    When  propionic  is  substituted  for  acetic  anhy- 
dride, propionylcode'ine  (propionylmethylmorphine)  is  formed ;  on  evapo- 
rating its  ethereal  solution,  this  is  left  as  a  colorless  film  easily  soluble 
in  ether,  benzene,  and  alcohol.    It  dissolves  in  sulphuric  acid  with  a 
bluish  tint,  which  turns  dark  blue  on  the  addition  of  a  trace  of  ferric 
chloride.    When  heated,  both  solutions  turn  dark  green.    It  yields 
crystallizable  salts  with  acids.    The  hydrochloride  crystallizes  in  large 
colorless  needles  containing  2H20,  and  soluble  in  water  and  alcohol ; 
it  gives  a  yellow  crystalline  platinochloride.    The  acetate  crystallizes 
in  colorless  needles  soluble  in  water.    It  loses  a  part  of  its  acetic  acid 
at  100°.    The  hydriodide  crystallizing  with  1  mol.  H20,  the  oxalate 
with  3H20,  and  the  sulphate  are  all  soluble  in  water.    Codeine  metho- 
chloride {methylmorphine  methochloride)  is  obtained  from  codeine  meth- 
iodide by  treatment  with  silver  chloride;  and  crystallizes  in  large 
rhombic  prisms  with  1  mol.  H20.     It  yields  a  yellow  flocculent 
platinochloride  with  3H20.    The  sulphate  gives  colorless  needles  con- 
taining 4H20.    A  solution  of  the  last-named  salt  yields,  with  barium 
hydroxide,  a  colorless  solution  of  codeine  methylhydroxide,  which  on  { 
evaporation  over  sulphuric  acid,  deposits  crystals  of  methocodeine 
(methylmorphimethine).    The  unchanged  hydroxide  solution  precipi- 
tates hydrates  from  solutions  of  metallic  salts,  and  rapidly  absorbs 
carbonic  anhydride  from  the  air.    Codeine  methiodide  dissolves  in 
acetic  anhydride  at  85°,  and  deposits  oblong  rectangular  tables  of 
acetylcodeine  methiodide  on  cooling.    Thus  obtained,  the  crystals  are 
anhydrous;  but  on  recrystallization  from  alcohol,  colorless  needles 
containing  4H20  are  obtained.    The  platinochloride  forms  a  yellow 
crystalline  precipitate.    If  a  solution  of  sodium,  potassium,  ammonium, 
barium,  or  calcium  hydroxide  be  added  to  an  aqueous  solution  of 
