Am.  Jour.  Pharm. 
Oct.,  1884. 
Quinine  and  Homoquinine. 
521 
dissolves  readily  in  water.  The  aqueous  solution  leaves  again  upon 
spontaneous  evaporation  an  amorphous  residue. 
Acid  Hydrochlorate  of  Homoquinine  is  obtained  upon  adding  some 
hydrochloric  acid  to  a  concentrated  aqueous  solution  of  the  neutral 
hydrochlorate ;  the  acid  hydrochlorate  separates  at  once  in  stout  color- 
less prisms,  which  dissolve  pretty  freely  in  water,  but  less  readily  in 
hydrochloric  acid. 
Acid  Chloroplatinate  of  Homoquinine. — Upon  mixing  an  aqueous 
solution  of  the  previous  salt  with  platinum  solution  a  pale  yellow  floc- 
culent  precipitate  results,  which  almost  immediately  is  re- arranged  in 
small  orange-red  prisms.  The  salt  contains  water  of  crystallization 
that  is  first  given  off  at  120°  C. 
Hydrosidphocyanide  of  Homoquinine  is  obtained  upon  mixing  a  solu- 
tion of  the  neutral  hydrochlorate  with  potassium  sulpho-cyanide.  It 
is  amorphous,  dissolves  slightly  in  cold  water,  but  more  freely  in  hot 
water  and  in  alcohol. 
Neutral  Sulphate  of  Homoquinine  is  obtained  ,  upon  saturation  of 
hot  dilute  sulphuric  acid  with  the  base.  Upon  cooling  of  the  solution 
the  sulphate  crystallizes  in  short  six-sided  colorless  prisms,  which 
being  very  brittle  are  broken  more  or  less  in  collection.  The  salt  dis- 
solves in  about  thirty  parts  of  boiling  water,  very  slightly  in  cold 
water,  freely  in  boiling  alcohol,  and  is  nearly  insoluble  in  chloroform 
and  ether. 
Samples  prepared  on  different  occasions  gave  upon  analysis  the  fol- 
lowing results  : 
I.  0-2490  gram  gave  at  120°  C.  0-0333  H20. 
II.  0-4848  gram  gave  at  120°  C.  0-0608  H20. 
III.  0-3300  gram  gave  at  120°  C.  0-0420  H20  and  0  0925  S04  Ba. 
IV.  0-2243  gram  gave  at  120°  C.  0*0293  H20. 
Calculated  for  Found. 
(C2oH24N202)2,S04H2+6H20.                    I.  II.            III.  IV. 
H20    .    .    12-64      ....    1337  12-50       12-85  13*01 
S03     .    .     9-37   -  ...  9*62 
The  crystals  of  this  salt  effloresce  superficially  in  air,  and  become 
consequently  dull ;  the  loss  of  water  is,  however,  not  worth  notice. 
Even  after  a  considerable  time  the  water  of  crystallization  amounts 
still  to  12*50  per  cent.  On  the  other  hand,  quinine  sulphate  exposed 
to  exactly  the  same  conditions  would  at  the  end  of  a  couple  of  hours 
have  fallen  to  a  powder,  and  would  then  contain  only  4*2  to  4*6  per 
cent,  of  water.    If  the  two  sulphates,  dehydrated  at  120°  C,  be  exposed 
