Am.  Jour.  Pharm. 
Dec,  1884. 
Hydrochlorate  of  Cocaine. 
613 
extent,  no  accurate  determination  had  been  made.  This  came  on  during 
the  pupillary  dilatation,  and  fully  returned  in  several  hours'  time. 
"  7.  In  each  case,  there  was  both  local  analgesia  and  anaesthesia. 
Sensation  of  pain  was  lost  wherever  the  drug  had  touched,  and  sensi- 
bility was  deadened  in  localized  areas.  These  evidenced  by  the  pinch- 
ing of  the  conjunctiva  with  forceps  without  causing  any  pain ;  whilst 
in  some  places  the  grasp  was  not  felt  at  all,  that  is,  when  care  was 
taken  not  to  exert  a  dragging  over  a  large  area  of  conjunctiva. 
"Conclusions : 
"  First.  Upon  account  of  the  evanescence  of  pupillary  dilatation 
and  the  quick  return  of  ciliary  power,  the  drug  will  be  of  great  value 
in  making  ophthalmoscopic  examinations  in  cases  dependent  upon  their 
use. 
"Second.  It  will  be  useful  in  cases  where  it  is  desired  to  introduce 
instruments  of  holding  or  fixation  beneath  the  lids.  Lachrymal  probes 
coated  with  ointments  containing  the  drug  may  be  of  advantage  in 
lessening  the  sensibility  of  the  passages  during  the  maintenance  of  the 
probe  in  position.  In  fact,  it  may  be  used  where  any  instrument  of 
precision  or  of  treatment  is  apt  to  cause  error,  inconvenience  or  harm 
by  pain  or  sensibility. 
"Third.  It  maybe  of  value  in  annulling  the  pain  from  applications 
of  cauterizing  agents,  strong  astringents,  etc.,  although  it  is  to  be 
remembered  that  the  tissues  may  be  rendered  momentarily  abnormal 
by  the  anaesthetic  to  such  an  extent  as  to  prevent  proper  actions  of  the 
astringent  or  cauterizing  material. 
"Fourth.  In  diseases  or  injuries  of  the  external  eye,  where  nerves 
are  exposed  or  irritated,  it  may  be  employed  with  much  soothing  bene- 
fit. Thus,  in  scratches  of  the  corneal  epithelium  or  of  the  conjunctiva, 
in  superficial  ulcerations  or  nerve  irritations,  it  may  be  of  inestimable 
good. 
"  Fifth.  It  may  be  of  value  in  various  surgical  operations  upon  those 
parts  of  the  eye  which  can  be  readily  reached  by  the  drug,  such  as  the 
extraction  of  foreign  bodies  from  the  cornea  and  conjunctiva,  slitting 
of  canaliculi,  extirpation  of  corneal  or  conjunctival  tumors,  etc. 
"Sixth.  It  may  be  of  service  as  a  local  haemastatic  in  cases  of  opera- 
tion  where  it  is  desired  to  follow  the  steps  of  the  procedure  without 
obstruction  from  clots  and  masses  of  blood,  or  as  a  remedial  agent  in 
arresting  haemorrhage  from  trauma  or  disease. 
"Seventh.  Judging  from  its  action  upon  the  iris  and  ciliary  muscle, 
