8 
Substitute  for  Ethyl  Alcohol. 
Am.  Jour.  Pharru. 
January.  1899. 
alkaloids  not  extracted  is  as  91  for  the  U.S.P.  menstruum  against 
27  for  the  acetic  acid  menstruum. 
Then  as  a  broad  general  result,  it  is  claimed  to  have  been  shown 
that  by  the  substitution  of  the  acetic  acid  menstruum  for  the  alco- 
holic, one-half  the  cost  of  grinding,  and  five-sixths  of  the  cost  oi 
menstruum  are  saved,  an  equivalent  product  being  obtained  in 
larger  quantity. 
NUX  VOMICA  REPERCOLATIONS. 
Three  Successive  Portions  of  500  Grammes  each  for  each  Menstruum. 
500  Gm. 
Portions. 
1st  Portion 
2d 
3d  " 
r  .  U.S.P.  Menstruum. 
Percolates  64'5  P-c-  Alcohol  with  a  small 
percolates.      proportion  of  Acetic  Acid. 
Acetic  acid  Menstruum. 
10  p.c.  Acetic  Acid. 
Weig't. 
Gm. 
Ex- 
tract. 
Gm. 
Chlo- 
rof 'rm 
Ext'ct. 
Gm. 
Alka- 
loids. 
Gm. 
Weig't. 
Gm. 
Ex- 
tract. 
Gm. 
Chl°-  Alka- 
rof'rm  f^ff' 
Ext'ct.  !^s- 
Gm.  Gm- 
1st  500  C.c. 
45776 
54-80 
1550 
10  56 
55I-2o 
78-00 
1200  II'I9 
1st  500  C.c. 
463-88 
60  "00 
17'50 
I2'0I 
538-10 
104-00 
16-00  13-74 
1st  500  C.c. 
47I,05 
72-50 
20-00 
I4'74 
539-69 
104-80 
2I"00  14-65 
2d  500  C.c. 
454-38 
30-50 
9*50 
5'46 
521-80 
51-50 
9-50  4-20 
3d  500  C.c. 
443*36 
2-50 
I  "00 
0-91 
508-36 
4-00 
0-50  0-27 
17th  Fraction 
88-65 
0*40 
0-16 
0-07 
101-70 
0-48 
o-oS  0*06 
Original  assays  .... 
43 '75 
42-00 
44-11 
43'95 
The  weighing  and  measurements  of  the  first  three  columns  of  the 
table  are  actual  upon  the  scale  of  the  figures  given.  Those  of  the 
other  columns  were  obtained  as  follows:  10  c.c.  was  accurately  meas- 
ured off  from  each  500  c.c.  of  percolate,  and  was  evaporated  until  it 
practically  ceased  to  lose  weight.  The  weight  of  this  extract  multi- 
plied by  50  is  given  in  columns  four  and  eight  as  being  the  extract 
present  in  the  500  c.c.  This  extract  from  10  c.c.  was  then  dissolved  in 
ammoniated  alcohol  and  the  alkaloid  shaken  out  with  chloroform 
and  ether  mixture.  The  chloroform  and  ether  were  boiled  off  and 
the  extract  dried  until  it  practically  ceased  to  lose  weight.  This 
weight  multiplied  by  50  is  given  in  columns  five  and  nine  as  being 
the  chloroform  extract  in  the  500  c.c.  of  percolate.  This  extract 
titrated  with  decinormal  acid  and  alkali  gave  the  total  alkaloids  in 
the  10  c.c,  which,  multiplied  by  50  gave  the  figures  of  columns  six 
and  ten.    Hence  all  these  figures  are  subject  to  the  risk  of  multipli- 
