232 
Pharmacological  Notes. 
Am.  Jour.  Pharm. 
May,  1899. 
PHARMACOLOGICAL  NOTES. 
STRONTIUM  BROMIDE  IN  EPILEPSY. 
Roche  (London  Lancet,  October  15,  1898)  renews  his  recom- 
mendation of  strontium  bromide  in  the  treatment  of  epilepsy,  and 
states  that  he  has  not  seen  any  case  in  which  it  will  not  diminish  the 
number  of  attacks  if  given  properly,  and  that  it  does  not  cause  the 
depression  that  sometimes  attends  the  use  of  potassium  bromide.  In 
cases  in  which  the  aura  is  sufficiently  prolonged,  the  patient  should 
take  30  grains  at  once,  and  repeat  the  dose  every  hour  if  required. 
In  this  way  the  attacks  are  frequently  warded  off.  Many  patients 
take  a  dram. daily  for  long  periods  without  ill-effects. — Phila.  Med, 
Jour.,  p.  946.  J.  L.  D.  M. 
LYSOL  POISONING. 
Heinrich  Cramer  (Centralblatt  fur  Gyndkologie,  October  1,  1898) 
reports  a  case  of  lysol  poisoning  in  a  primipara,  twenty-two  years 
of  age,  following  a  normal  labor,  after  a  vaginal  douche  of  4  liters 
of  1  per  cent,  solution  of  lysol  had  been  used.  On  the  afternoon  of 
the  same  day  there  was  a  slight  rise  of  temperature,  and  a  second 
douche  was  given.  After  1  y2  liters  of  the  solution  had  been  used 
the  patient  became  suddenly  restless,  her  breathing  heavy,  her  eyes 
rolled  and  she  lost  consciousness,  and  her  pulse  was  very  rapid  and 
feeble.  The  douching  was  stopped  and  the  patient  regained  con- 
sciousness in  three  minutes,  but  complained  of  feeling  dizzy  and 
sank  into  a  condition  of  stupor.  On  the  next  day  the  urine  was 
dark  brown,  contained  blood  casts,  numerous  broken-down  red 
blood-corpuscles  and  0*3  per  cent,  of  albumin.  The  general  con- 
dition became  worse  from  day  to  day,  and  death  resulted  after  a 
week.  Upon  necropsy,  endometritis,  parametritis  and  endophlebi- 
tis  of  the  uterus  were  found,  with  hemorrhagic  inflammation  of  the 
kidneys.  Cramer  mentions  a  considerable  number  of  cases  of  lysol- 
poisoning,  and  believes  that  the  drug  should  be  used  with  care,  and 
that  the  amount  of  fluid  used  should  be  taken  into  consideration,  as 
well  as  its  concentration. — Phila.  Med.  Jour.,  p.  1066.    J.  L.  D.  M. 
COMPOSITION  OF  DIPHTHERIA  TOXIN. 
P.  Ehrlich  (Deutsche  Med.  Woch.,  No.  38)  states  beside  the  essen- 
tial toxin  in  diphtheria  poison,  there  are  other  substances  very  much 
less  toxic,  "toxoids,"  which  are  important,  however,  as  they  bind 
