258 
Hydrastine  Hexiodide. 
Am.  Jour.  Pliarm. 
June,  1899. 
But  if  the  order  of  mixing  be  reversed,  that  is,  the  weak  alka- 
loidal  solution  added  to  a  large  excess  of  iodine,  a  definite  and 
unique  periodide,  namely,  hydrastine  hydriodide  pentiodide  is 
always  formed.  This  body  is  prepared  according  to  the  general 
method  of  making  the  higher  alkaloidal  periodides,  described  by 
us  in  the  previous  paper.1  The  hexiodide  thus  made  is  a  very  dark 
brown  powder,  very  difficultly  soluble  in  ether,  benzol  or  cold  chloro- 
form, more  readily  in  hot  chloroform  and  in  alcohol,  and  very  easily 
in  a  mixture  of  alcohol  and  chloroform,  or  of  alcohol  and  ether. 
In  hot  water  it  melts  to  a  resinous  mass.  Attempts  to  crystallize  it 
have  failed,  as  on  evaporation  of  the  solvent  it  always  remains  a 
resinous  mass. 
Both  in  the  hydrastine  hexiodide  and  the  lower  compound,  that 
approaching  a  triiodide  in  composition,  the  so-called  additive  iodine 
was  estimated  by  dissolving  the  substance  in  a  small  quantity  of  a 
mixture  of  alcohol  and  chloroform,  and  titrating  with  standard  sodium 
thiosulphate.  For  the  estimation  of  total  iodine  in  these  compounds, 
the  substance  was  treated  with  zinc  and  ammonia,  the  iodine  then 
liberated  by  means  of  a  solution  of  nitrous  acid  in  concentrated 
sulphuric  acid,  and  taken  up  with  carbon  disulphide.  The  details 
were  carried  out  exactly  as  described  in  our  paper  on  morphine 
tetraiodide.2 
For  Additive  Iodine. — 0-1371  of  substance  were  found  to  contain 
°'°75833  of  additive  iodine,  and  0-1623  of  substance  0  0898344  addi- 
tive iodine. 
For  Total  Iodine. — 0-1491  substance  contained  0-0996800  total 
iodine,  and  0-1429  contained  0-0958333  total  iodine. 
ANALYSIS  OF  THE  HYDRASTINE  HEXIODIDE. 
Found. 
55-30 
55'34 
Calculated  for 
C21H21NOGHI.I5 
55*43 
2 
Found. 
66-86 
66 -06 
Calculated  for 
C^HaiNOcHI.Ii 
66-52 
2 
1  Loc.  cit. 
2  Proc.  Am.  P/'iar.  Assoc.,  1898,  Vol.  46,  p.  364. 
