AmjJu°nUe?iS19arm'}  Hydrastine  Hexiodide.  259 
ANALYSIS  OF  THE  LOWER  PERIODIDE  OF  HYDRASTINE,  APPROACHING  A 
TRIIODIDE. 
For  Total  Iodine. — 0*2674  contained  o 1337328  total  iodine,  and 
0*2396  contained  o  1191752  total  iodine. 
Calculated  for 
Found.  CgiHsiNOeHI.L, 
I   5Q-OI  49*83 
2   49  74 
For  Additive  Iodine. — 009535  contained  0*0340975  free  iodine, 
0*1737  contained  0-0626681  free  iodine  0-1215  contained, 
0-044 1 395, .and  0-2328  contained  0-0838545  free  iodine. 
Calculated  for 
Found.  C81H8]NOcHI.Io 
1  ...  •   35  76  33*22 
2   36"07 
3  -  •  •  36-33 
4  •  •  "  •   36-02 
In  the  iodometric  estimation  of  hydrastine  the  exclusive  forma- 
tion of  the  hexiodide  is  assured  by  adding  a  weak  solution  of 
the  alkaloidal  salt  to  a  large  excess  of  iodine.  The  estimation 
is  carried  out  in  the  same  way  as  described  by  us  in  a  previous 
paper.1 
The  factor  for  hydrastine  is  0-60403  : 
(382-14  :  5  x  126-53. : :  0*60403  :  1). 
In  order  to  test  this  factor,  two  solutions  of  hydrastine2  in  acidu- 
lated water  were  prepared,  containing  0-3  per  cent,  and  0-15  per 
cent,  of  the  free  alkaloid  respectively,  and  the  estimation  of  the 
strength  of  the  solutions  carried  out  exactly  as  described  in  the 
above-mentioned  paper.  The  results  were  as  follows  :  20  c.c.  of  the 
first  (0-3  per  cent.)  solution  consumed  0-0970001  gramme  free  iodine 
and  25  c.c.  of  the  second  (o-i  5  per  cent.)  solution  consumed  0  061 1461 
free  iodine. 
STRENGTH  OF  THE  SOLUTIONS. 
Actually 
Found.  contained. 
1   0*29  O-30 
2  .  .  .  .  ... .  ;         .   0*14  0*15 
1  Proc.  Am.  Phar.  Assoc.,  46,  368;  /.  Am.  Chcm.  Soc,  20,  722. 
2  We  are  indebted  to  Prof.  John  U.  Lloyd,  of  Cincinnati,  for  a  specially  pre- 
pared sample  of  hydrastine.  We  had  also  a  sample  in  a  lot  of  pure  alkaloids 
kindly 'furnished  us  by  Merck  &  Co.  These  two  samples  agreed  very  well  with 
each  other  in  the  quantitative  results. 
