THE  AMERICAN 
JOURNAL  OF  PHARMACY 
ON    ACETIC  ACID   AS    A  SUBSTITUTE   FOR  ETHYL 
ALCOHOL  IN  EXTRACTING  THE  ACTIVE  PRIN- 
CIPLES OF  SOME  OFFICINA.L  DRUGS. 
By  Edward  R.  Souibb,  M.D.,  of  Brooklyn,  N.  Y. 
(second  paper.) 
In  continuing  this  subject  for  a  second  paper  the  writer  refers  to, 
without  repeating,  the  introductory  matter  of  the  first  paper,  where 
the  therapeutic  and  pharmaceutic  bearings  of  such  a  substitution 
are  discussed  and  passes  at  once  to  the  farther  work  which  is  re- 
lied upon  to  support  or  oppose  the  proposed  substitution  and  define 
the  limits  of  its  application. 
In  the  meantime,  it  may  be  well  to  state  that  the  guarded  use  of 
extracts  and  fluid  extracts  made  with  acetic  acid  has  continued  and 
extended  in  veterinary  therapeutics  with  only  favorable  reports,  so 
that  such  a  class  of  preparations  may  fairly  be  considered  as  estab- 
lished for  veterinary  practice  where  the  large  quantities  used  make 
the  reduced  cost  a  very  important  consideration.  Some  hospitals  are 
also  still  using  them  in  increasing  quantities  without  discoverable 
objection.  The  number  of  physicians  known  to  be  using  them  in 
private  practice,  though  not  yet  large,  is  increasing,  and  no  serious 
disadvantages  have  been  developed  by  close  and  careful  observation  . 
In  selecting  a  drug  for  competitive  investigation  in  this  second 
paper,  cinchona  was  selected  first  on  account  of  its  importance,  next 
on  account  of  the  difficulty  there  has  always  been  in  finding  a 
proper  menstruum, — next  on  account  of  the  difficulty  of  exhaus- 
tion by  any  menstruum  hitherto  known,  and  finally  on  account  of 
the  very  considerable  amount  of  time  and  work  that  the  writer  has 
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