l'}      Tincture  of  Fat-Free  Digitalis.  343 
SUMMARY  OF  RESULTS. 
Fat-Free  Tincture. 
Official  Tincture. 
Case. 
First 
Effect, 
Minutes. 
,  Full 
Effect, 
Minutes. 
Work  or 
Beats 
Reduced. 
First 
Effect, 
Minutes. 
Full 
Effect, 
Minutes. 
Work  or 
Beats 
Reduced. 
15 
75 
8 
30 
60 
6 
15 
60 
30 
8 
15 
60 
c 
0 
30 
QO 
5 
4.  . 
15 
45 
8 
30 
75 
6 
5  •  • 
15 
45 
6 
3° 
60 
15 
45 
12 
30 
60 
15 
45 
10 
30 
60 
6 
>5 
45 
8 
30 
60 
8 
9  •  • 
15 
45 
8 
'  IS1 
60 
10 
15 
30 
6 
30 
30 
2 
15 
9 
30 
105 
9 
15 
45 
6 
30 
60 
8 
13-  ■ 
15 
45 
10 
30 
45 
6 
14.  . 
15 
45 
3 
45 
105 
6 
15  •  • 
15 
60 
8 
45 
45 
4 
Averages  .  .  . 
15 
49 
y6 
3i 
66 
6-4 
h — hypodermic  cases  ;  others,  by  mouth. 
1  Exceptional  case.    Explained  in  text. 
Twelve  of  the  above  patients  were  male  and  three  female.  In 
twelve  of  the  cases  the  tinctures  were  given  by  the  mouth,  and  in 
three,  hypodermically,  which  latter  are  so  marked. 
From  these  results  it  may  be  said  that,  practically,  the  primary 
effects  of  the  fat-free  tincture  were  manifested  in  1 5  minutes,  and 
the  maximum  in  45  minutes ;  while,  with  the  official  tincture,  pri- 
mary effects  were  evidenced  in  30  minutes,  and  the  maximum  in 
60  minutes.  In  both  cases,  however,  the  duration  of  effect  was  the 
same — 30  minutes.  The  pulse  reduction,  or  work  done,  was  slightly 
greater  with  the  fat-free  tincture  than  with  the  official.  The  most 
striking  difference,  however,  exhibited  between  the  fat-free  tincture 
and  the  official  tincture  was  the  much  greater  rapidity  of  absorption 
and  action  of  the  former — showing  a  more  speedy  assimilation 
of  the  fat-free  product.  The  time  element  of  drug  action  is  a  very 
important  matter  in  some  cases,  and  might  readily  mean,  with  a 
