Am.  Jour.  Pharm.l 
June,  1891.  j 
}   Syrup  of  Hypophosphites  with  Iron. 
279 
Freshly  precipitated  ferric  hypophosphite  is  by  far  more  soluble 
than  the  dry  salt  and  by  triturating  it  with  boiling  hot  U.  S.  P. 
syrup  of  the  hypophosphites  an  almost  complete  solution  may  be 
effected. 
This  is,  however,  not  stable,  as  some  of  the  iron  will  redeposit  on 
cooling. 
If  in  this  operation  in  place  of  the  officinal  syrup  one  containing 
hypophosphorous  acid  is  employed,  solubility  is  less  complete  and 
the  green  color  of  the  iron  salt  destroyed. 
Simple  solution  not  being  possible,  advantage  was  taken  of  the 
solvent  action  of  citrates  upon  ferric  hypophosphite.  The  follow- 
ing formula  is  based  mainly  upon  the  one  given  in  the  National 
Formulary  for  compound  syrup  of  the  hypophosphites  and  if 
carefully  manipulated,  will  furnish  a  stable  and  attractive  prepara- 
tion : 
Hypophosphite  of  calcium,  180  grs. 
Water,  a  sufficient  quantity  to  make  8  ounces. 
Mix  the  hypophosphites  of  calcium,  sodium  and  potassium 
and  triturate  with  3  ounces  of  water,  adding  the  citric  acid  to 
effect  complete  solution  of  the  calcium  salt,  and  filter.  To  the 
filtrate,  introduced  into  a  bottle,  add  the  sugar. 
Dissolve  the  iron  and  the  citrate  in  6  drachms  of  water  with  the 
aid  of  heat,  filter  the  resulting  green  solution  and  allow  to  cool. 
The  perfectly  cold  solution  is  added  to  the  contents  of  the  bottle 
and  the  sugar  dissolved  by  agitation.  If  it  be  desired,  lemon  spirit  may 
added  to  flavor. 
The  iron  solution  must  be  perfectly  cold  or  citrate  of  calcium  is 
precipitated  and  the  syrup  rendered  cloudy.  It  may  also  be  stated, 
that  freshly  precipitated  iron  hypophosphite  requires  less  potassium 
citrate  for  solution  than  the  dry  salt. 
Thus  prepared  the  syrup  is  of  a  yellowish  green  color  and  agree- 
able taste.  It  contains  the  same  amount  of  iron  as  the  officinal 
syrup  and  on  two  weeks'  standing  shows  no  change. 
sodium, 
potassium, 
60  grs. 
60  grs. 
48  grs. 
50  grs. 
5  grs. 
6  oz. 
iron, 
Citrate  of  potassium, 
Citric  acid,  .... 
Granulated  sugar,  . 
