Am'ju?iey*iS)iarm'}  Gleanings  from  the  German  Journals.  289 
variable  in  amount  (from  0-3-07  per  cent.);  some  of  the  extracts 
although  quite  efficient  did  not  contain  appreciable  quantities  of 
the  acid.  He  quotes  Dr.  Poulson  :  "  The  crystallized  filicic  acid  is 
absolutely  inert ;  the  amorphous  acid  is  very  poisonous  and  upon 
it  depends  the  efficiency  of  the  extract  of  male-fern."  Prof.  Kobert 
states  the  Russian  extract  is  about  ten  times  more  powerful  than  the 
German,  and  twenty  times  more  powerful  than  the  French  extract. 
5  gm.  of  the  Russian  extract  will  produce  dangerous  poisoning- 
symptoms,  while  the  German  extract  is  given  in  five  to  eight 
grams  doses,  by  Dr.  Gerhardt,  even  16  gms. — Pharm.  Ztg.,  1891, 
246. 
Tonquinol,  an  artificial  preparation  of  musk- like  odor,  is  placed 
upon  the  market  by  Valentiner  and  Schwarz,  of  Leipzig  ;  it  forms  a 
white  crystalline  powder  mixed  with  needle-shaped  crystals,  and  is 
stated  to  be  made  by  nitrating  a  terpene  and  a  xylol-sulphonic 
acid.  The  substance  is  especially  recommended  for  soaps  and  per- 
fumes ;  the  alcoholic  solution  (1  : 50)  can  be  diluted  to  any  degree, 
differing  in  this  respect  from  the  artificial  musk  of  Baur  (Am.  Journ. 
Pharm.,  1890,  489).  F.  Eichbaum  (in  Scifenfabrikant,  1891,  154), 
speaks  of  tonquinol  as  not  being  altered  in  the  least  by  exposure  to 
air,  light  and  alkalies  ;  as  being  soluble  in  most  solvents  as 
fats,  oils,  ether,  chloroform,  etc.  Compared  with  genuine  musk  and 
artificial  musk  Baur  in  price  per  kilo  is  stated  :  Genuine  musk, 
$700,  artificial  musk  $600  and  tonquinol  $450;  in  small  quantities 
tonquinol  sells  at  50  cents  per  gram. — Pharm.  Ztg.,  189 1,  222. 
Phenocollum  hydrochloricHin,  a  new  antipyretic  and  anti-rheumatic 
manufactured  by  the  Chemische  Fabrik  auf  Actien  (formerly  E 
Schering),  is  a  phenacetine  (C6H4(OC2H5)NHC2H30)  derivative  in 
which  the  amido  group  (NH2)  is  introduced  into  the  acetyl  radicle. 
It  is  made  by  action  of  glycocol  (or  amido-acetic  acid  CH2NH2COOH 
upon  phenetidine  C6H4(OC2H5)NH2  one  molecule  of  water  split- 
ting off.  The  compound  is  the  hydrochlorate  of  amido-acet-para- 
phenetidine  C6H4(OC2K5)NHCH2NH2CO.  It  is  soluble  in  i6partsof 
water  at  1 7°C,  forming  a  neutral  solution;  from  boiling  water  it  crystal- 
lizes in  cubes,  from  alcohol  in  needles.  The  aqueous  solution  is  pre- 
cipitated by  ammonium,  potassium  and  sodium  hydrates,  and  alka- 
line carbonates,  the  base  separating  with  one  molecule  of  water  of 
crystallization  ;  the  anhydrous  base  melts  at  100  5  0  C,  the  hydrous  at 
95  °C.    In  doses  of  one  gram  it  reduces  fever- temperatures  nearly 
