A_m.  Jour.  Pharm. 
July,  1891 
Chemical  Notes. 
339 
are  precipitated  on  boiling  the  solution.  Sabadine  crystallizes  from 
ether  in  short  needles,  and  in  the  crystalline  state  is  difficultly  soluble 
in  water  and  ether.  The  fusing  point  is  238-2400  C,  where  decom- 
position takes  place.  On  complete  evaporation  of  the  etheral  solu- 
tion the  last  portions  remain  as  an  amorphous  mass,  which  gradually 
crystallizes.  Concentrated  sulphuric  acid  dissolves  the  alkaloid  with 
a  yellow  color  and  a  green  fluorescence  ;  this  disappears  as  the  liquid 
assumes  a  blood-red  and  then  violet  color.  Sabadine  is  not  sternu- 
tatory, and  has  the  formula  C29H51N08.  Sabadinine  crystallizes 
from  ether  in  filiform  needles,  somewhat  soluble  in  water  and  rather 
soluble  in  alcohol.  At  a  higher  temperature,  decomposition  takes 
place.  Concentrated  sulphuric  acid  dissolves  the  alkaloid  with  an 
unchangeable  blood-red  color.  Sabadinine  is  not  sternutatory,  and 
possesses  the  formula  C27H43N08  or  C27H45N08. 
A  new  Alkaloid  from  Conium  maculatum. — E.  Merck  (1.  c, 
through  Chem.  Centrbl.,  91, 1,  414)  obtained  a  small  quantity  of  a 
new  alkaloid  from  the  high  boiling  portion  of  crude  coniine.  .  The 
isolation  was  accomplished  by  fractional  distillation  in  vacuo  and 
recrystallization.  The  alkaloid  crystallizes  in  needles,  is  easily  solu- 
ble in  alcohol,  ether  and  chloroform,  fuses  at  about  980  C,  and  boils 
at  230-2320  C.  According  to  Ladenburg,  the  alkaloid  is  an 
isomere  of  conhydrine,  having  the  formula  C8HirNO,  and  for  this 
reason  the  name  psendo-co?ihydrine  was  selected. 
Muazvine. — E.  Merck  (1.  c.)  isolated  this  alkaloid  from  the  bark 
of  the  Muawi  tree  (not  determined).  The  bark  possesses  toxic 
properties  similar  to  those  of  sassy  bark  (Erythrophlceum  guineense), 
only  acting  stronger  and  quicker.  The  alkaloid  is  thick,  syrupy, 
easily  soluble  in  alcohol,  ether  and  chloroform,  and  resembles 
erythrophlceine.  The  salts  do  not  crystallize,  the  bromhydrate 
forming  a  white  powder  easily  soluble  in  water,  alcohol  and  chloro- 
form. According  to  Kobert  the  physiological  action  is  similar  to, 
but  not  identical  with,  that  of  erythrophlceine. 
Reactions  of  Cocaine  and  Ec go  nine. — D.  Vitali  {LOrosi,  14,  I  — 19) 
proposes  the  following  test  for  cocaine.  A  trace  of  cocoaine  is 
placed  in  a  porcelain  capsule,  ]/2-\  cc.  of  sulphuric  acid  added,  and 
solution  of  the  alkaloid  effected.  To  this  is  added  iodate  of 
potassium,  or  sodium,  or  iodic  acid  in  quantity  equal  to  three  times 
that  of  cocaine.    If  this  mixture  is  slightly  heated  on  a  water-bath, 
