Amjuiy'iSi.arm'}  Gleanings  from  the  German  Journals.  345 
and  then  a  solution  of  100  oil  of  anise  in  240  0  alcohol  added.  After 
standing  the  clear  portion  is  decanted,  the  turbid  residue  filtered. — 
Dietel,  Pharm.  Ztg.,  1891,  322. 
Ethylene  Bromide,  which  has  so  frequently  been  substituted  for 
ethyl  bromide,  is  being  recommended  and  introduced  by  Dr.  Donath 
{Wiener  Med.  Bl.y  1891,  279)  as  a  remedy  for  epilepsy ;  it  is  given  in 
doses  of  o-i  to  0-3  gram  three  times  a  day.  The  forms  in  which  it 
should  be  administered,  owing  to  insolubility  in  water,  are  emul- 
sions ;  or  alcoholic  solution  largely  diluted  with  milk  before  taking  ; 
or  in  gelatin  capsules  with  oil  of  sweet  almonds.  The  remedy,  in 
physical  properties,  odor  and  taste,  resembles  chloroform ;  sp.  gr. 
2-163  at  2I°  C.;  boiling  point  131 0  C;  it  contains  90  per  cent, 
bromine  and  is  insoluble  in  water,  but  soluble  in  alcohol  and  fixed 
oils. — Pharm.  Ztg.,  1891,  322. 
Salicyl-bromanilide  is  a  combination  introduced  by  Radlauer 
which  is  said  to  contain  bromacetanilide  and  salicylanilide  and  to 
unite  the  desirable  properties  of  acetanilide,  bromine  and  salicylic 
acid.  It  is  a  white  powder  with  an  unpleasant,  somewhat  acidulous 
taste,  sparingly  soluble  in  cold  water,  easily  soluble  in  boiling  water, 
alcohol  and  ether;  the  dose  varies  from  0-2-0-6  gm. ;  it  is  used  as 
an  antinervine  and  reliable  antipyretic.  Salbromanilide  is  a  term 
that  has  been  given  to  this  compound  for  the  sake  of  brevity. — 
Pharm.  Ztg.,  1891,  323. 
Iodophenine,  a  new  iodine  derivative  of  phenacetine,  is  obtained 
by  adding  solution  of  iodine  in  potassium  iodide  to  a  hydrochloric 
acid  solution  of  phenacetine'.  It  is  made  upon  a  large  scale  by  dis- 
solving 600  gm.  phenacetine  in  5  kgm.  glacial  acetic  acid,  adding  a 
solution  of  900  gm.  hydrochloric  acid  in  3  kgm.  water  and,  lastly,  a 
solution  of  680  gm.  iodine  in  1,360  gm.  potassium  iodide  and  1,360 
gm.  water ;  if  the  phenacetine  solution  be  used  warm,  upon  cooling 
the  new  compound  separates  in  crystals  closely  resembling  potas- 
sium permanganate.  Iodophenine  possesses  a  faint  iodine-like  odor, 
has  a  burning  taste  and  colors  the  skin  yellow ;  it  is  soluble  in 
glacial  acetic  acid  and  in  alcohol ;  insoluble  or  nearly  so  in  water, 
in  benzol,  chloroform  and  50  per  cent,  acetic  acid.  The  iodine  is 
very  easily  liberated,  heating  alone  or  boiling  with  water  accom- 
plishing this;  it  contains  51  per  cent,  iodine  and  has  given  encour- 
aging results  as  an  antiseptic  and  a  febrifuge. — Dr.  L.  Scholvien, 
Pharm.  Centralhalle,  1891,  311. 
