Am.  Jour.  Pharm. ) 
Aug.,  1891.  J 
Haplopappus  Baylahnen. 
379 
the  result  of  modifying  the  urine  and  diminishing  the  bad  odor.  In 
the  treatment  of  ulcers,  applying  its  collodion  to  the  wound  gives 
an  antiseptic  covering,  which  excludes  the  contact  of  air  and  of 
micro-organisms  and  facilitates  cicatrization.  The  infusion  has 
given  us  the  best  results  and  it  is  in  the  infusion  that  we  advise  the 
use  of  Hysterionica." 
In  the  Therapeutic  Gazette,  15,  67,  Dr.  H.  Gilbert  states  that 
Haplopappus  Baylahuen  is  of  the  utmost  value  in  chronic  diarrhoea. 
The  infusion  of  the  drug  was  examined  for  a  crystalline  principle, 
but  all  efforts  in  that  direction  have  as  yet  failed,  tannin  being  the 
only  important  constituent  found. 
The  resin  which  constitutes  a  large  portion  of  the  drug  (21-15  per 
cent.)  was  examined.  Tn  order  to  obtain  it  the  drug,  in  moderately 
fine  powder,  was  mixed  with  coarsely  powdered  glass  ;  placed  in  a 
"  Gomberg's  extraction  apparatus,"  and  extracted  with  alcohol  until 
the  menstruum  came  through  nearly  colorless,  which  took  from  18 
to  24  hours,  after  which  the  resin  was  obtained  by  the  usual 
method. 
After  trying  many  methods  for  the  separation  of  the  resin  the 
following  was  found  the  most  satisfactory. 
The  resin  was  treated  with  a  one-fourth  saturated  solution  of 
sodium  hydroxide,  raised  to  the  boiling  point,  when  two  layers 
were  formed,  one  dark  green  and  thick,  the  other  brown  and  clear. 
The  brown  solution  was  syphoned  off  and  when  cold,  to  it  was 
added  a  solution  of  barium  chloride,  which  formed  a  light  greenish 
yellow  precipitate  (a)  and  a  light  yellow  supernatant  liquid. 
The  green  solution  was  dissolved  in  hot  water  and  while  hot 
barium  chloride  was  added.  A  precipitate  {b)  green  in  color  and 
somewhat  darker  than  {a)  was  obtained.  The  supernatant  liquid 
was  dark  reddish  color. 
Alpha. — The  light  greenish  yellow  precipitate  [a]  on  being 
decomposed  by  hydrochloric  acid  gave  a  dark  brown  precipitate 
which  was  difficultly  soluble  in  alcohol. 
Beta. — The  yellow  supernatant  liquid  from  (a)  was  made  acid  with 
hydrochloric  acid,  giving  a  yellow  amorphous  precipitate,  which 
after  being  dissolved  in  alcohol  and  the  alcohol  evaporated,  a  soft 
solid  resin  remained. 
Gamma. — The  precipitate  (b)  after  treatment  with  hydrochloric 
acid  gave  a  granular  green  precipitate,  which  settled  very  rapidly 
into  a  cake. 
